SCHEMBL1499168

SCHEMBL1499168

N#CCC(CN1CCN(C(=O)c2ccc(C#N)cc2F)CC1)n1cc(-c2ncnc3[nH]ccc23)cn1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TYRO3 Q06418 2/20 1.00
AXL P30530 2/20 0.81
MERTK Q12866 2/20 0.81
JAK2 O60674 17/20 0.56
JAK1 P23458 9/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16517737 1.00 TYRO3 (1.00) TYRO3AXLMERTKJAK2JAK1
SCHEMBL16517808 1.00 TYRO3 (1.00) TYRO3AXLMERTKJAK2JAK1
Trifluoroacetic Acid SCHEMBL1498923 0.96 TYRO3 (0.92) TYRO3AXLMERTKJAK2JAK1
SCHEMBL22622447 0.93 TYRO3 (0.87) TYRO3AXLMERTKJAK2JAK1
SCHEMBL18054734 0.93 TYRO3 (0.87) TYRO3AXLMERTKJAK2JAK1
SCHEMBL2088539 0.93 TYRO3 (0.87) TYRO3AXLMERTKJAK2JAK1
SCHEMBL1499241 0.92 TYRO3 (0.86) TYRO3AXLMERTKJAK2JAK1
SCHEMBL2084853 0.92 TYRO3 (0.86) TYRO3AXLMERTKJAK2JAK1
SCHEMBL22061837 0.92 TYRO3 (0.85) TYRO3AXLMERTKJAK2JAK1
SCHEMBL2086936 0.92 TYRO3 (0.85) TYRO3AXLMERTKJAK2JAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 286 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4565229-A1 TREATMENT OF URTICARIA USING JAK INHIBITORS Incyte Corporation (US) 2025-06-11 EP claimed
CN-119768166-A Treatment of urticaria using JAK inhibitors 因赛特公司 2025-04-04 CN claimed
EP-4501409-A2 TREATMENT OF B-CELL MALIGNANCIES BY A COMBINATION JAK AND PI3K INHIBITOR Incyte Holdings Corporation (US) 2025-02-05 EP claimed
EP-3773593-B1 TREATMENT OF HIDRADENITIS SUPPURATIVA USING JAK INHIBITORS INCYTE CORP (US) 2024-05-15 EP claimed
US-20240091234-A1 TREATMENT OF B-CELL MALIGNANCIES BY A COMBINATION JAK AND PI3K INHIBITORS INCYTE CORPORATION 2024-03-21 US claimed
US-20240058343-A1 TREATMENT OF URTICARIA USING JAK INHIBITORS INCYTE CORPORATION 2024-02-22 US claimed
WO-2024030600-A1 TREATMENT OF URTICARIA USING JAK INHIBITORS INCYTE CORPORATION (US) 2024-02-08 WO claimed
CN-117120055-A Combination therapy comprising a JAK pathway inhibitor and a ROCK inhibitor 因赛特公司 2023-11-24 CN claimed
EP-4274578-A1 COMBINATION THERAPY COMPRISING JAK PATHWAY INHIBITOR AND ROCK INHIBITOR Incyte Corporation (US) 2023-11-15 EP claimed
US-20220378791-A1 JAK1 INHIBITORS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROMES INCYTE CORPORATION 2022-12-01 US claimed
US-20160000795-A1 TREATMENT OF B-CELL MALIGNANCIES BY A COMBINATION JAK AND PI3K INHIBITORS INCYTE CORPORATION (US) 2016-01-07 US claimed
WO-2015184305-A1 TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 INCYTE CORPORATION (US) 2015-12-03 WO claimed
US-20150342952-A1 TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 INCYTE CORPORATION (US) 2015-12-03 US claimed
WO-2015157257-A1 TREATMENT OF B-CELL MALIGNANCIES BY A COMBINATION JAK AND PI3K INHIBITOR INCYTE CORPORATION (US) 2015-10-15 WO claimed
WO-2015131031-A1 JAK1 INHIBITORS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROMES INCYTE CORPORATION (US) 2015-09-03 WO claimed
US-20150246046-A1 JAK1 INHIBITORS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROMES INCYTE CORPORATION 2015-09-03 US claimed
US-20150065447-A1 SURVIVAL BENEFIT IN PATIENTS WITH SOLID TUMORS WITH ELEVATED C-REACTIVE PROTEIN LEVELS INCYTE CORPORATION (US) 2015-03-05 US claimed
WO-2015026818-A1 SURVIVAL BENEFIT IN PATIENTS WITH SOLID TUMORS WITH ELEVATED C-REACTIVE PROTEIN LEVELS INCYTE CORPORATION (US) 2015-02-26 WO claimed
WO-2011028685-A1 HETEROCYCLIC DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-D]PYRIMIDINES AS JANUS KINASE INHIBITORS INCYTE CORPORATION (US) 2011-03-10 WO claimed
US-20110059951-A1 HETEROCYCLIC DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS INCYTE CORPORATION 2011-03-10 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160000795-A1 TREATMENT OF B-CELL MALIGNANCIES BY A COMBINATION JAK AND PI3K INHIBITORS JAK2, JAK1, BTK TYRO3 280/4885AXL 889/4885MERTK 452/4885
US-20220378791-A1 JAK1 INHIBITORS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROMES JAK1, JAK2, JAK3 TYRO3 284/4885AXL 1052/4885MERTK 447/4885
US-20150065447-A1 SURVIVAL BENEFIT IN PATIENTS WITH SOLID TUMORS WITH ELEVATED C-REACTIVE PROTEIN LEVELS JAK2, STAT3, IL6 TYRO3 326/4885AXL 589/4885MERTK 172/4885
US-20150246046-A1 JAK1 INHIBITORS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROMES JAK1, JAK2, JAK3 TYRO3 284/4885AXL 1052/4885MERTK 447/4885
US-20110059951-A1 HETEROCYCLIC DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS JAK3, JAK1, JAK2 TYRO3 107/4885AXL 296/4885MERTK 515/4885
US-20150342952-A1 TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 JAK1, JAK2, MCL1 TYRO3 947/4885AXL 1833/4885MERTK 293/4885
US-20240091234-A1 TREATMENT OF B-CELL MALIGNANCIES BY A COMBINATION JAK AND PI3K INHIBITORS JAK2, JAK1, BTK TYRO3 280/4885AXL 889/4885MERTK 452/4885
US-20240058343-A1 TREATMENT OF URTICARIA USING JAK INHIBITORS JAK1, JAK3, JAK2 TYRO3 116/4885AXL 559/4885MERTK 507/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.