Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GPR3 | P46089 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11327423 | 0.80 | MAPT (0.47) | CYP1A2ALDH1A1MAPTKDM4EGPR3 | |
| SCHEMBL27809942 | 0.77 | CYP1A2 (0.48) | CYP1A2ALDH1A1MAPTKDM4EGPR3 | |
| SCHEMBL31003174 | 0.77 | CYP1A2 (0.48) | CYP1A2ALDH1A1MAPTKDM4EGPR3 | |
| SCHEMBL103601 | 0.75 | MAPT (0.62) | CYP1A2ALDH1A1MAPTKDM4EGPR3 | |
| SCHEMBL29364974 | 0.75 | MAPT (0.62) | CYP1A2ALDH1A1MAPTKDM4EGPR3 | |
| Water SCHEMBL27809943 | 0.75 | CYP1A2 (0.47) | CYP1A2ALDH1A1MAPTKDM4EGPR3 | |
| SCHEMBL27694211 | 0.75 | MAPT (0.50) | CYP1A2ALDH1A1MAPTKDM4EGPR3 | |
| SCHEMBL29589829 | 0.74 | TDP1 (0.58) | CYP1A2ALDH1A1MAPTKDM4ENQO2 | |
| SCHEMBL19535296 | 0.74 | TDP1 (0.58) | CYP1A2ALDH1A1MAPTKDM4ENQO2 | |
| SCHEMBL19535302 | 0.74 | MAPT (0.42) | CYP1A2ALDH1A1MAPTKDM4ENQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9464087-B2 | Difluoromethylation of unsaturated compounds | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-10-11 | — | — | US | disclosed |
| US-9464087-B2 | Difluoromethylation of unsaturated compounds | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-10-11 | — | — | US | disclosed |
| US-9464087-B2 | Difluoromethylation of unsaturated compounds | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-10-11 | — | — | US | disclosed |
| EP-2785723-B1 | DIFLUOROMETHYLATION OF UNSATURATED COMPOUNDS | SCRIPPS RESEARCH INST (US) | 2016-10-05 | — | — | EP | disclosed |
| EP-2785723-B1 | DIFLUOROMETHYLATION OF UNSATURATED COMPOUNDS | SCRIPPS RESEARCH INST (US) | 2016-10-05 | — | — | EP | disclosed |
| US-20150011760-A1 | Difluoromethylation Of Unsaturated Compounds | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-01-08 | — | — | US | disclosed |
| US-20150011760-A1 | Difluoromethylation Of Unsaturated Compounds | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-01-08 | — | — | US | disclosed |
| US-20150011760-A1 | Difluoromethylation Of Unsaturated Compounds | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-01-08 | — | — | US | disclosed |
| EP-2785723-A1 | DIFLUOROMETHYLATION OF UNSATURATED COMPOUNDS | The Scripps Research Institute (US) | 2014-10-08 | — | — | EP | disclosed |
| WO-2013082028-A1 | DIFLUOROMETHYLATION OF UNSATURATED COMPOUNDS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-06-06 | — | — | WO | disclosed |
| WO-2013082028-A1 | DIFLUOROMETHYLATION OF UNSATURATED COMPOUNDS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-06-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150011760-A1 | Difluoromethylation Of Unsaturated Compounds | ZRANB2, FDPS, NISCH | CYP1A2 1360/4885ALDH1A1 1448/4885MAPT 3723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.