Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 17/20 | 0.66 |
| ▸ | BCL2 | P10415 | 9/20 | 0.66 |
| ▸ | MCL1 | Q07820 | 9/20 | 0.66 |
| ▸ | BCL2A1 | Q16548 | 5/20 | 0.66 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.51 |
| ▸ | LDHA | P00338 | 3/20 | 0.50 |
| ▸ | LDHB | P07195 | 3/20 | 0.50 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14995970 | 0.92 | BCL2L1 (0.64) | BCL2L1BCL2MCL1BCL2A1BCL2L2 | |
| SCHEMBL2622283 | 0.86 | BCL2L1 (0.60) | BCL2L1BCL2MCL1BCL2A1BCL2L2 | |
| SCHEMBL14995997 | 0.83 | BCL2L1 (0.50) | BCL2L1BCL2MCL1BCL2A1BCL2L2 | |
| SCHEMBL2528280 | 0.82 | BCL2L1 (0.61) | BCL2L1BCL2MCL1BCL2A1BCL2L2 | |
| SCHEMBL14995987 | 0.81 | BCL2L1 (0.51) | BCL2L1BCL2MCL1BCL2A1BCL2L2 | |
| SCHEMBL1892776 | 0.80 | BCL2L1 (0.79) | BCL2L1BCL2MCL1BCL2A1BCL2L2 | |
| SCHEMBL2532052 | 0.80 | BCL2L1 (1.00) | BCL2L1BCL2MCL1BCL2A1BCL2L2 | |
| SCHEMBL14995998 | 0.79 | BCL2L1 (0.47) | BCL2L1BCL2MCL1BCL2A1LDHA | |
| SCHEMBL14995968 | 0.79 | BCL2L1 (0.43) | BCL2L1BCL2MCL1BCL2A1BCL2L2 | |
| SCHEMBL2529200 | 0.78 | BCL2L1 (0.58) | BCL2L1BCL2MCL1BCL2A1BCL2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455540-B2 | Gossypol and apogossypol derivatives, preparation thereof and uses thereof | UNIVERSITE DU MAINE (LE MANS) (FR) | 2013-06-04 | — | — | US | disclosed |