Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.32 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | POLRMT | O00411 | 1/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.31 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.31 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.30 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL881455 | 1.00 | ADORA2A (0.37) | ADORA2ATMPRSS2PI4KAPI4K2BPI4K2A | |
| SCHEMBL12243240 | 0.89 | ADORA2A (0.38) | ADORA2ATMPRSS2PI4KAPI4K2BPI4K2A | |
| SCHEMBL16519851 | 0.89 | ADORA2A (0.38) | ADORA2ATMPRSS2PI4KAPI4K2BPI4K2A | |
| SCHEMBL10148586 | 0.88 | TMPRSS2 (0.35) | TMPRSS2 | |
| SCHEMBL12397055 | 0.88 | TMPRSS2 (0.35) | TMPRSS2 | |
| SCHEMBL881391 | 0.88 | ADORA2A (0.35) | ADORA2ATMPRSS2PI4KAPI4K2BPI4K2A | |
| SCHEMBL19242543 | 0.86 | ADORA2A (0.34) | ADORA2ATMPRSS2PI4KAPI4K2BPI4K2A | |
| SCHEMBL881450 | 0.84 | ADORA2A (0.33) | ADORA2ATMPRSS2PI4KAPI4K2BPI4K2A | |
| SCHEMBL881677 | 0.84 | TMPRSS2 (0.40) | ADORA2ATMPRSS2PI4KAPI4K2BPI4K2A | |
| SCHEMBL10149670 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455451-B2 | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment | GILEAD SCIENCES, INC. (US) | 2013-06-04 | — | — | US | disclosed |