Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT6A | Q92794 | 1/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3092400 | 0.91 | KAT6A (0.50) | KAT6AACACBLARS1BCL2KDM4E | |
| SCHEMBL3092758 | 0.89 | KAT6A (0.47) | KAT6AACACBLARS1BCL2KDM4E | |
| SCHEMBL15000148 | 0.88 | LARS1 (0.45) | LARS1KDM4EALDH1A1KMT2ATPSAB1 | |
| SCHEMBL3084604 | 0.86 | LMNA (0.44) | KAT6ALARS1KDM4E | |
| SCHEMBL15000037 | 0.83 | LARS1 (0.49) | LARS1KDM4EALDH1A1KMT2ATPSAB1 | |
| SCHEMBL3093062 | 0.83 | NPC1 (0.48) | LARS1KDM4E | |
| SCHEMBL3091266 | 0.81 | LMNA (0.44) | KAT6ALARS1KDM4EKMT2A | |
| SCHEMBL14999941 | 0.80 | LARS1 (0.53) | KAT6ALARS1KDM4EALDH1A1KMT2A | |
| SCHEMBL3088704 | 0.80 | LARS1 (0.40) | KAT6ALARS1KDM4EALDH1A1KMT2A | |
| SCHEMBL3089105 | 0.80 | LARS1 (0.40) | KAT6ALARS1KDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2172450-B9 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2014-10-08 | — | — | EP | disclosed |
| EP-2172450-B1 | NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2013-10-16 | — | — | EP | disclosed |
| US-8461209-B2 | Malonic acid sulfonamide derivative and pharmaceutical use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2013-06-11 | — | — | US | disclosed |