Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 2/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.39 |
| ▸ | NEK1 | Q96PY6 | 2/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL427443 | 0.88 | IKBKB (0.40) | IKBKBPRKAG1PRKAA1NEK1PRKAB1 | |
| SCHEMBL427482 | 0.86 | IKBKB (0.39) | RAB9AHPGDIKBKBPRKAG1PRKAA1 | |
| SCHEMBL14993995 | 0.86 | PDE4D (0.34) | RAB9AIKBKBPRKAG1PRKAA1NEK1 | |
| SCHEMBL430745 | 0.84 | IKBKB (0.39) | RAB9AIKBKBPRKAG1PRKAA1NEK1 | |
| SCHEMBL427461 | 0.83 | IKBKB (0.41) | IKBKBPRKAG1PRKAA1NEK1PRKAB1 | |
| SCHEMBL16204000 | 0.82 | KDM4E (0.39) | RAB9AHPGDIKBKBPRKAG1PRKAA1 | |
| SCHEMBL427477 | 0.81 | IKBKB (0.39) | RAB9AIKBKBPRKAG1PRKAA1NEK1 | |
| SCHEMBL430421 | 0.81 | KDM4E (0.39) | RAB9AHPGDIKBKBPRKAG1PRKAA1 | |
| SCHEMBL428531 | 0.81 | IKBKB (0.38) | RAB9AHPGDIKBKBPRKAG1PRKAA1 | |
| SCHEMBL427534 | 0.81 | IKBKB (0.38) | RAB9AIKBKBPRKAG1PRKAA1NEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2785181-B1 | 2-(SUBSTITUTED-PHENYL)-CYCLOPENTANE-1,3-DIONE COMPOUNDS, AND DERIVATIVES THEREOF | SYNGENTA LTD (GB) | 2016-08-17 | — | — | EP | disclosed |
| WO-2013079708-A1 | 2-(SUBSTITUTED-PHENYL)-CYCLOPENTANE-1,3-DIONE COMPOUNDS, AND DERIVATIVES THEREOF | SYNGENTA LIMITED (GB) | 2013-06-06 | — | — | WO | disclosed |