Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.35 |
| ▸ | AKT1 | P31749 | 3/20 | 0.34 |
| ▸ | AKT2 | P31751 | 3/20 | 0.34 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.34 |
| ▸ | ECE1 | P42892 | 2/20 | 0.34 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.34 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.34 |
| ▸ | PRKX | P51817 | 1/20 | 0.34 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.34 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15005624 | 0.79 | MAP2 (0.42) | ROCK2ROCK1AKT1AKT3PRKACA | |
| SCHEMBL3597383 | 0.75 | ATM (0.42) | CYP3A4TRPV1 | |
| SCHEMBL3597380 | 0.75 | ATM (0.42) | CYP3A4TRPV1 | |
| SCHEMBL3597387 | 0.75 | ATM (0.42) | CYP3A4TRPV1 | |
| SCHEMBL15005797 | 0.72 | CDC7 (0.39) | ROCK2ROCK1AKT1AKT3PRKACA | |
| SCHEMBL3597459 | 0.70 | MAP2 (0.48) | CLK4 | |
| SCHEMBL15005727 | 0.70 | CDC7 (0.37) | ROCK2ROCK1TRPV1AKT1AKT3 | |
| SCHEMBL3608210 | 0.70 | DHODH (0.44) | ROCK2ROCK1AKT1AKT3PRKACA | |
| SCHEMBL15005240 | 0.69 | CDC7 (0.40) | ROCK2ROCK1TRPV1AKT1AKT3 | |
| SCHEMBL27738852 | 0.66 | CYP3A4 (0.71) | CYP3A4ECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118102-B1 | TRICYCLIC INDOLES AND (4,5-DIHYDRO) INDOLES | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-06-12 | — | — | EP | claimed |