Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.37 |
| ▸ | ROS1 | P08922 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.34 |
| ▸ | GCGR | P47871 | 2/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15005240 | 0.90 | CDC7 (0.40) | CDC7RPS6KB1ROS1TRPV1MAPK12 | |
| SCHEMBL3600494 | 0.83 | CDC7 (0.40) | CDC7RPS6KB1ROS1TRPV1MAPK12 | |
| SCHEMBL15005624 | 0.81 | MAP2 (0.42) | CDC7RPS6KB1MAPK12PIM1GSK3B | |
| SCHEMBL15005797 | 0.80 | CDC7 (0.39) | CDC7RPS6KB1MAPK12MAPK13MAPK11 | |
| SCHEMBL3594823 | 0.80 | CDC7 (0.45) | CDC7RPS6KB1ROS1TRPV1MAPK12 | |
| SCHEMBL3598022 | 0.76 | ERN1 (0.45) | CDC7RPS6KB1MAPK12MAPK13GCGR | |
| SCHEMBL3603414 | 0.73 | CDC7 (0.43) | CDC7RPS6KB1MAPK12MAPK13MAPK11 | |
| SCHEMBL3608210 | 0.72 | DHODH (0.44) | CDC7RPS6KB1MAPK12PIM1GSK3B | |
| SCHEMBL3597459 | 0.70 | MAP2 (0.48) | CDC7IMPDH2CLK4CDK8CDK5 | |
| SCHEMBL15005688 | 0.70 | ROCK2 (0.36) | TRPV1GSK3BROCK1CLK4ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118102-B1 | TRICYCLIC INDOLES AND (4,5-DIHYDRO) INDOLES | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-06-12 | — | — | EP | claimed |