Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 8/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 6/20 | 0.33 |
| ▸ | CDK1 | P06493 | 6/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 6/20 | 0.33 |
| ▸ | CCNK | O75909 | 1/20 | 0.32 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.32 |
| ▸ | CDK2 | P24941 | 3/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.32 |
| ▸ | CDK9 | P50750 | 2/20 | 0.32 |
| ▸ | CDK7 | P50613 | 1/20 | 0.31 |
| ▸ | CCNH | P51946 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.30 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15028075 | 1.00 | CDK5 (0.33) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL15028204 | 0.82 | MEN1 (0.31) | — | |
| SCHEMBL21253842 | 0.82 | CDK5 (0.41) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL2359481 | 0.81 | CCNE2 (0.48) | CCNE1CDK2AHRCCNE2 | |
| SCHEMBL20895830 | 0.81 | CCNE2 (0.48) | CCNE1CDK2AHRCCNE2 | |
| SCHEMBL2317462 | 0.81 | CCNE2 (0.48) | CCNE1CDK2AHRCCNE2 | |
| SCHEMBL20895831 | 0.81 | CCNE2 (0.48) | CCNE1CDK2AHRCCNE2 | |
| SCHEMBL2317472 | 0.81 | CCNE2 (0.48) | CCNE1CDK2AHRCCNE2 | |
| SCHEMBL30476574 | 0.81 | CCNE2 (0.48) | CCNE1CDK2AHRCCNE2 | |
| SCHEMBL30013436 | 0.81 | CCNE2 (0.48) | CCNE1CDK2AHRCCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013086436-A1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2013-06-13 | — | — | WO | disclosed |