Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 3/20 | 0.67 |
| ▸ | PKN1 | Q16512 | 3/20 | 0.67 |
| ▸ | PAK4 | O96013 | 2/20 | 0.67 |
| ▸ | PAK3 | O75914 | 2/20 | 0.65 |
| ▸ | PAK2 | Q13177 | 2/20 | 0.65 |
| ▸ | WEE1 | P30291 | 1/20 | 0.63 |
| ▸ | CDK4 | P11802 | 6/20 | 0.57 |
| ▸ | CCND1 | P24385 | 6/20 | 0.57 |
| ▸ | CCND2 | P30279 | 6/20 | 0.57 |
| ▸ | CCND3 | P30281 | 6/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13554022 | 0.92 | PAK1 (0.78) | PAK1PKN1PAK4PAK3PAK2 | |
| SCHEMBL13554053 | 0.91 | WEE1 (0.68) | PAK1PKN1PAK4PAK3PAK2 | |
| SCHEMBL15030203 | 0.88 | PAK1 (0.67) | PAK1PKN1PAK4PAK3PAK2 | |
| SCHEMBL15030195 | 0.87 | PAK1 (0.71) | PAK1PKN1PAK4PAK3PAK2 | |
| SCHEMBL15030196 | 0.87 | PAK1 (0.66) | PAK1PKN1PAK4PAK3PAK2 | |
| SCHEMBL14824679 | 0.86 | PAK1 (0.62) | PAK1PKN1PAK4PAK3PAK2 | |
| SCHEMBL15035991 | 0.84 | PAK1 (0.69) | PAK1PKN1PAK4PAK3PAK2 | |
| SCHEMBL13553528 | 0.84 | PAK1 (0.69) | PAK1PKN1PAK4PAK3PAK2 | |
| SCHEMBL14824677 | 0.83 | PAK1 (0.78) | PAK1PKN1PAK4PAK3PAK2 | |
| SCHEMBL6808498 | 0.83 | CDK4 (0.74) | PAK1PKN1PAK4PAK3PAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013086451-A2 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-13 | — | — | WO | disclosed |