Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | KHK | P50053 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15443901 | 0.88 | CHRM1 (0.35) | TP53TDP1CHRM1KHK | |
| SCHEMBL19981539 | 0.83 | CHRM2 (0.33) | CHRM1KHK | |
| SCHEMBL15443789 | 0.80 | TSHR (0.36) | TP53TDP1 | |
| SCHEMBL14654986 | 0.80 | MAPK1 (0.41) | TP53TDP1CHRM1 | |
| SCHEMBL21316777 | 0.79 | GNAO1 (0.36) | — | |
| SCHEMBL14655015 | 0.78 | MAPK1 (0.43) | TP53TDP1CHRM1 | |
| SCHEMBL15443760 | 0.76 | MEN1 (0.41) | TP53TDP1CHRM1 | |
| SCHEMBL408996 | 0.72 | — | — | |
| SCHEMBL18993493 | 0.72 | — | — | |
| SCHEMBL15443801 | 0.71 | TSHR (0.37) | TP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788487-B1 | OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA | SAREPTA THERAPEUTICS INC (US) | 2018-04-04 | — | — | EP | disclosed |
| EP-2788488-B1 | METHODS FOR TREATING PROGEROID LAMINOPATHIES USING OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA | SAREPTA THERAPEUTICS INC (US) | 2018-03-21 | — | — | EP | disclosed |
| US-9682097-B2 | Oligonucleotide analogues targeting human LMNA | SAREPTA THERAPEUTICS, INC. (US) | 2017-06-20 | — | — | US | disclosed |
| WO-2013086444-A2 | METHODS FOR TREATING PROGEROID LAMINOPATHIES USING OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA | SAREPTA THERAPEUTICS, INC. (US) | 2013-06-13 | — | — | WO | disclosed |