Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | TPMT | P51580 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.30 |
| ▸ | SELE | P16581 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1188757 | 0.84 | MLYCD (0.43) | MLYCDCLK1DYRK1ADYRK1BTRPM8 | |
| SCHEMBL1194431 | 0.83 | MLYCD (0.42) | MLYCDCLK1DYRK1ADYRK1BTRPM8 | |
| SCHEMBL1193980 | 0.83 | MLYCD (0.42) | MLYCDCLK1DYRK1ADYRK1BTRPM8 | |
| SCHEMBL1169591 | 0.83 | MLYCD (0.42) | MLYCDCLK1DYRK1ADYRK1BTRPM8 | |
| SCHEMBL4719735 | 0.83 | TPMT (0.46) | MLYCDCLK1DYRK1ADYRK1BABCB1 | |
| SCHEMBL6493529 | 0.83 | MLYCD (0.45) | MLYCDCLK1DYRK1ADYRK1BABCB1 | |
| SCHEMBL13746764 | 0.80 | MLYCD (0.40) | MLYCDCLK1DYRK1ADYRK1BTRPM8 | |
| SCHEMBL3716405 | 0.79 | MLYCD (0.43) | MLYCDCLK1DYRK1ADYRK1BABCB1 | |
| SCHEMBL1194738 | 0.79 | MLYCD (0.39) | MLYCDCLK1DYRK1ADYRK1BABCB1 | |
| SCHEMBL1169078 | 0.79 | ATM (0.47) | MLYCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240179-B1 | IMIDAZOPYRIDAZINE AS PAR1 INHIBITORS, THEIR MANUFACTURE AND THEIR APPLICATION AS MEDICINE | SANOFI SA (FR) | 2016-08-17 | — | — | EP | disclosed |
| US-9079906-B2 | Triazolopyridazines as PAR1 inhibitors, production thereof, and use as medicaments | SANOFI (FR) | 2015-07-14 | — | — | US | disclosed |
| US-8853206-B2 | Triazolium salts as PAR1 inhibitors, production thereof, and use as medicaments | SANOFI (FR) | 2014-10-07 | — | — | US | disclosed |
| US-8466169-B2 | SF5 derivatives as PAR1 inhibitors, production thereof, and use as medicaments | SANOFI (FR) | 2013-06-18 | — | — | US | disclosed |