Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 5/20 | 0.49 |
| ▸ | DRD2 | P14416 | 4/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 4/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | DRD1 | P21728 | 2/20 | 0.47 |
| ▸ | DRD5 | P21918 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | PRCP | P42785 | 1/20 | 0.47 |
| ▸ | EBP | Q15125 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4697447 | 1.00 | DRD3 (0.49) | DRD3DRD2OPRM1OPRK1DRD4 | |
| SCHEMBL10389820 | 1.00 | DRD3 (0.49) | DRD3DRD2OPRM1OPRK1DRD4 | |
| SCHEMBL973131 | 1.00 | DRD3 (0.49) | DRD3DRD2OPRM1OPRK1DRD4 | |
| SCHEMBL6926415 | 0.80 | SLC6A2 (0.55) | SIGMAR1 | |
| SCHEMBL14609043 | 0.80 | SLC6A2 (0.55) | SIGMAR1 | |
| SCHEMBL15046981 | 0.79 | DRD3 (0.73) | DRD3DRD2OPRM1DRD4SIGMAR1 | |
| SCHEMBL10274630 | 0.76 | DRD2 (0.69) | DRD3DRD2DRD4SIGMAR1HTR1A | |
| SCHEMBL23923588 | 0.75 | HTR2A (0.56) | — | |
| SCHEMBL23923444 | 0.75 | HTR2A (0.56) | — | |
| SCHEMBL23940041 | 0.75 | HTR2A (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013086496-A2 | 1-SUBSTITUTED 4-ARYLPIPERAZINE AS KAPPA OPIOID RECEPTOR ANTAGONISTS | RESEARCH TRIANGLE INSTITUTE (US) | 2013-06-13 | — | — | WO | disclosed |