Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | EDNRB | P24530 | 2/20 | 0.40 |
| ▸ | EDNRA | P25101 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15031925 | 0.87 | MAPK1 (0.39) | CYP1A2MAPK1ALDH1A1EDNRBEDNRA | |
| SCHEMBL11545008 | 0.82 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2APBRM1POLB | |
| SCHEMBL15010031 | 0.81 | ALDH1A1 (0.44) | CYP1A2MAPK1ALDH1A1MAPTMEN1 | |
| Dimethylamine SCHEMBL11269567 | 0.78 | ALDH1A1 (0.56) | MAPK1ALDH1A1PBRM1GAATNKS2 | |
| SCHEMBL29123169 | 0.74 | TP53 (0.50) | CYP1A2MAPK1MAPTMEN1KMT2A | |
| SCHEMBL6669536 | 0.74 | PBRM1 (0.46) | CYP1A2MAPK1EDNRBEDNRAAR | |
| SCHEMBL28345186 | 0.72 | ALDH1A1 (0.67) | CYP1A2MAPK1ALDH1A1EDNRBEDNRA | |
| SCHEMBL17075818 | 0.72 | CYP1A2 (0.47) | CYP1A2MAPK1EDNRBEDNRAAR | |
| SCHEMBL29440612 | 0.72 | CYP1A2 (0.47) | CYP1A2MAPK1EDNRBEDNRAAR | |
| SCHEMBL29440609 | 0.72 | CYP1A2 (0.47) | CYP1A2MAPK1EDNRBEDNRAAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9012443-B2 | Bicyclic aryl and heteroaryl sodium channel inhibitors | AMGEN INC. (US) | 2015-04-21 | — | — | US | disclosed |
| US-20130150339-A1 | Bicyclic Aryl and Heteroaryl Sodium Channel Inhibitors | AMGEN INC. (US) | 2013-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150339-A1 | Bicyclic Aryl and Heteroaryl Sodium Channel Inhibitors | SCN1A, SCN1B, CACNA1B | CYP1A2 399/4885MAPK1 697/4885ALDH1A1 795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.