Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 12/20 | 0.64 |
| ▸ | PRKDC | P78527 | 1/20 | 0.64 |
| ▸ | TTK | P33981 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.31 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10143289 | 0.92 | PIK3CG (0.65) | PIK3CGPRKDCTTKSIK2ADORA2A | |
| SCHEMBL10143102 | 0.92 | PIK3CG (0.65) | PIK3CGPRKDCTTKSIK2ADORA2A | |
| SCHEMBL10143288 | 0.92 | PIK3CG (0.65) | PIK3CGPRKDCTTKSIK2ADORA2A | |
| SCHEMBL10142563 | 0.91 | PIK3CG (0.77) | PIK3CGPRKDCTTKADORA2AADORA2B | |
| SCHEMBL20056882 | 0.91 | PIK3CG (0.77) | PIK3CGPRKDCTTKADORA2AADORA2B | |
| SCHEMBL19446166 | 0.91 | PIK3CG (0.77) | PIK3CGPRKDCTTKADORA2AADORA2B | |
| SCHEMBL19446154 | 0.89 | PIK3CG (0.69) | PIK3CGPRKDCTTKADORA2AADORA2B | |
| SCHEMBL19446223 | 0.88 | PIK3CG (0.63) | PIK3CGPRKDCTTKPIM1PIM3 | |
| SCHEMBL10143064 | 0.87 | PIK3CG (0.67) | PIK3CGPRKDCTTKADORA2AADORA2B | |
| SCHEMBL10143098 | 0.87 | PIK3CG (0.83) | PIK3CGPRKDCTTKPIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466288-B2 | Isoindolinone inhibitors of phosphatidylinositol 3-kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-06-18 | — | — | US | disclosed |
| US-8466288-B2 | Isoindolinone inhibitors of phosphatidylinositol 3-kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-06-18 | — | — | US | disclosed |