Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PPIA | P62937 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27926498 | 0.87 | PARP10 (0.43) | PARP10KDM4EHTTPARP1PDE4D | |
| SCHEMBL1503118 | 0.80 | PARP10 (0.44) | PARP10KDM4EPTPN1PLAUL3MBTL1 | |
| SCHEMBL2264921 | 0.78 | PTPN1 (0.48) | PARP10KDM4EPTPN1PDE4DMAPT | |
| SCHEMBL12444294 | 0.77 | P4HTM (0.44) | KDM4EPDE4DP4HTM | |
| SCHEMBL24257791 | 0.74 | PTPN1 (0.49) | PTPN1P4HTMMAPTMAPK1TDP1 | |
| SCHEMBL15064968 | 0.74 | AOC3 (0.59) | AOC3P4HTMMAPTMAPK1TDP1 | |
| SCHEMBL2220214 | 0.73 | NPC1 (0.48) | KDM4E | |
| SCHEMBL9741052 | 0.72 | KDM4E (0.48) | PARP10KDM4EMAP4K4P4HTM | |
| SCHEMBL13577662 | 0.72 | EGLN1 (0.42) | PARP10KDM4EHTTP4HTMMAPT | |
| SCHEMBL2840715 | 0.72 | LTA4H (0.59) | PARP10HTTPARP1PPIA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8742123-B2 | HIV integrase inhibitors from pyridoxine | TAIMED BIOLOGICS, INC. (TW) | 2014-06-03 | — | — | US | disclosed |
| EP-2300433-A1 | HIV INTEGRASE INHIBITORS FROM PYRIDOXINE | Ambrilia Biopharma Inc. (CA) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009146555-A1 | HIV INTEGRASE INHIBITORS FROM PYRIDOXINE | AMBRILIA BIOPHARMA INC. (CA) | 2009-12-10 | — | — | WO | disclosed |