Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 20/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | PTAFR | P25105 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6892948 | 0.85 | GRM2 (0.56) | GRM2CYP3A4 | |
| SCHEMBL15168586 | 0.76 | GRM2 (0.53) | GRM2PTAFRHTR2B | |
| SCHEMBL1503048 | 0.72 | GRM2 (0.68) | GRM2CYP3A4 | |
| SCHEMBL1502967 | 0.72 | GRM2 (1.00) | GRM2 | |
| SCHEMBL2393697 | 0.70 | DPP4 (0.44) | CYP3A4 | |
| SCHEMBL1502983 | 0.70 | GRM2 (0.65) | GRM2CYP3A4PTAFRHTR2B | |
| SCHEMBL6890181 | 0.69 | GRM2 (0.77) | GRM2 | |
| SCHEMBL6891457 | 0.69 | GRM2 (0.72) | GRM2CYP3A4 | |
| SCHEMBL6891434 | 0.69 | GRM2 (0.56) | GRM2 | |
| SCHEMBL6894419 | 0.69 | GRM2 (0.83) | GRM2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | claimed |
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | disclosed |