SCHEMBL1503226

SCHEMBL1503226

C=CC[C@@]1(C(=O)O)CCCN1C(=O)CN

nearest known ligand 0.36

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CD274 Q9NZQ7 1/20 0.32
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1503225 1.00 CD274 (0.32) CD274NPC1RAB9A
SCHEMBL9733790 0.84 CD274 (0.33) CD274NPC1RAB9A
SCHEMBL26832986 0.81
SCHEMBL17024347 0.81
SCHEMBL11500645 0.80 MEN1 (0.32) CD274
SCHEMBL9735306 0.80 MEN1 (0.32) CD274
SCHEMBL9735303 0.80 MEN1 (0.32) CD274
SCHEMBL5553779 0.78 DPP4 (0.35) CD274NPC1RAB9A
SCHEMBL28492715 0.78 CD274 (0.35) CD274NPC1RAB9A
SCHEMBL28492716 0.78 CD274 (0.35) CD274NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3024463-B1 NEUROPROTECTIVE BICYCLIC COMPOUNDS AND METHODS FOR THEIR USE IN TREATING AUTISM SPECTRUM DISORDERS AND NEURODEVELOPMENTAL DISORDERS NEUREN PHARMACEUTICALS LTD (NZ) 2020-03-25 EP claimed
US-20260001882-A1 PROCESS FOR PREPARING BICYCLIC GLYCINE-PROLINE COMPOUNDS AND MONOCYCLIC GLYCINE-PROLINE INTERMEDIATES THEREOF NEUREN PHARMACEUTICALS LTD (NZ) 2026-01-01 US disclosed
EP-4419528-A1 PROCESS FOR PREPARING BICYCLIC GLYCINE-PROLINE COMPOUNDS AND MONOCYCLIC GLYCINE-PROLINE INTERMEDIATES THEREOF Neuren Pharmaceuticals Limited (NZ) 2024-08-28 EP disclosed
CN-118234729-A Process for preparing bicyclic glycine-proline compounds and monocyclic glycine-proline intermediates thereof 诺仁制药有限公司 2024-06-21 CN disclosed
US-20240132511-A1 TREATMENTS OF PRADER-WILLI SYNDROME NEUREN PHARMACEUTICALS LIMITED (NZ) 2024-04-25 US disclosed
EP-4291192-A1 TREATMENTS OF PRADER-WILLI SYNDROME Neuren Pharmaceuticals Limited (NZ) 2023-12-20 EP disclosed
CN-116916921-A Treatment of Prader-Willi syndrome 诺仁制药有限公司 2023-10-20 CN disclosed
US-20230301994-A9 BICYCLIC COMPOUNDS AND METHODS FOR THEIR USE IN TREATING PITT HOPKINS SYNDROME NEUREN PHARMACEUTICALS LIMITED (NZ) 2023-09-28 US disclosed
WO-2023064991-A1 PROCESS FOR PREPARING BICYCLIC GLYCINE-PROLINE COMPOUNDS AND MONOCYCLIC GLYCINE-PROLINE INTERMEDIATES THEREOF NEUREN PHARMACEUTICALS LIMITED (NZ) 2023-04-27 WO disclosed
US-20220387426-A1 BICYCLIC COMPOUNDS AND METHODS FOR THEIR USE IN TREATING PITT HOPKINS SYNDROME NEUREN PHARMACEUTICALS LTD (NZ) 2022-12-08 US disclosed
US-9119851-B2 Cyclic Glycyl-2-Allyl Proline improves cognitive performance in impaired animals NEUREN PHARMACEUTICALS, LTD. (NZ) 2015-09-01 US disclosed
WO-2015013397-A2 NEUROPROTECTIVE BICYCLIC COMPOUNDS AND METHODS FOR THEIR USE IN TREATING AUTISM SPECTRUM DISORDERS AND NEURODEVELOPMENTAL DISORDERS NEUREN PHARMACEUTICALS LIMITED (NZ) 2015-01-29 WO disclosed
US-20140309230-A1 Cyclic Glycyl-2-Allyl Proline Improves Cognitive Performance in Impaired Animals NEUREN PHARMACEUTICALS LIMITED (NZ) 2014-10-16 US disclosed
US-8791117-B2 Cyclic glycyl-2-allyl proline improves cognitive performance in impaired animals NEUREN PHARMACEUTICALS LIMITED (NZ) 2014-07-29 US disclosed
US-8519127-B2 Cyclic glycyl-2-allyl proline and its use in treatment of peripheral neuropathy NEUREN PHARMACEUTICALS LIMITED (AU) 2013-08-27 US disclosed
US-20110201614-A1 CYCLIC GLYCYL-2-ALLYL PROLINE IMPROVES COGNITIVE PERFORMANCE IN IMPAIRED ANIMALS NEUREN PHARMACEUTICALS LIMITED (AU) 2011-08-18 US disclosed
WO-2011037644-A1 CYCLIC GLYCYL-2-ALLYL PROLINE AND ITS USE IN TREATMENT OF PERIPHERAL NEUROPATHY NEUREN PHARMACEUTICALS LIMITED (NZ) 2011-03-31 WO disclosed
US-20110052531-A1 CYCLIC GLYCYL-2-ALLYL PROLINE AND ITS USE IN TREATMENT OF PERIPHERAL NEUROPATHY NEUREN PHARMACEUTICALS LIMITED (AU) 2011-03-03 US disclosed
US-20090263334-A1 Cyclic Glycyl-2-Allyl Proline Improves Cognitive Performance in Impaired Animals BICKERDIKE MIKE JOHN 2009-10-22 US disclosed
WO-2008063311-A2 CYCLIC GLYCYL-2-ALLYL PROLINE IMPROVES COGNITIVE PERFORMANCE IN IMPAIRED ANIMALS NEUREN PHARMACEUTICALS LIMITED (NZ) 2008-05-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110052531-A1 CYCLIC GLYCYL-2-ALLYL PROLINE AND ITS USE IN TREATMENT OF PERIPHERAL NEUROPATHY PMP22, IAPP, GCG CD274 4326/4885NPC1 2943/4885RAB9A 2901/4885
US-20240132511-A1 TREATMENTS OF PRADER-WILLI SYNDROME COMT, HSD17B3, HSD3B1 CD274 4874/4885NPC1 2075/4885RAB9A 2566/4885
US-20110201614-A1 CYCLIC GLYCYL-2-ALLYL PROLINE IMPROVES COGNITIVE PERFORMANCE IN IMPAIRED ANIMALS GRIA2, QPCT, GRM2 CD274 4758/4885NPC1 1683/4885RAB9A 2119/4885
US-20090263334-A1 Cyclic Glycyl-2-Allyl Proline Improves Cognitive Performance in Impaired Animals GRIA2, QPCT, GRM2 CD274 4758/4885NPC1 1683/4885RAB9A 2119/4885
US-20230301994-A9 BICYCLIC COMPOUNDS AND METHODS FOR THEIR USE IN TREATING PITT HOPKINS SYNDROME QPCT, GRIA2, GGPS1 CD274 4812/4885NPC1 785/4885RAB9A 2743/4885
US-20140309230-A1 Cyclic Glycyl-2-Allyl Proline Improves Cognitive Performance in Impaired Animals GRIA2, QPCT, GRM2 CD274 4758/4885NPC1 1683/4885RAB9A 2119/4885
US-20220387426-A1 BICYCLIC COMPOUNDS AND METHODS FOR THEIR USE IN TREATING PITT HOPKINS SYNDROME QPCT, GRIA2, GGPS1 CD274 4812/4885NPC1 785/4885RAB9A 2743/4885
US-20260001882-A1 PROCESS FOR PREPARING BICYCLIC GLYCINE-PROLINE COMPOUNDS AND MONOCYCLIC GLYCINE-PROLINE INTERMEDIATES THEREOF GLRA2, GLRB, GLRA1 CD274 4759/4885NPC1 687/4885RAB9A 652/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.