HSD3B1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Finasteride (SCHEMBL5509)	1.00	1/20
Finasteride (SCHEMBL11909)	1.00	1/20
Finasteride (SCHEMBL952350)	1.00	1/20
Finasteride (SCHEMBL1560981)	1.00	1/20
Finasteride (SCHEMBL3982016)	1.00	1/20
Finasteride (SCHEMBL5148287)	1.00	1/20
Finasteride (SCHEMBL6448111)	1.00	1/20
SCHEMBL8611352	1.00	1/20
SCHEMBL2297747	0.82	1/20
SCHEMBL2294804	0.81	1/20
SCHEMBL2294809	0.81	1/20
SCHEMBL7111122	0.81	1/20
SCHEMBL2293254	0.80	1/20
SCHEMBL2293256	0.80	1/20
SCHEMBL4173615	0.80	1/20
SCHEMBL8378899	0.78	1/20
SCHEMBL2294373	0.78	1/20
SCHEMBL2294377	0.78	1/20
SCHEMBL8157426	0.76	1/20
SCHEMBL8157430	0.76	1/20

Clinical trials — most relevant to HSD3B1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Congenital Adrenal Hyperplasia Once Daily Hydrocortisone Treatment	PHASE4	RECRUITING
Comparisons of Different Forms of Glucocorticoid on the Recovery of Reproductive Function in Patients With 21α-hydroxylase Deficiency	PHASE4	UNKNOWN
Testosterone Treatment in a Patient With 17β-hydroxysteroid Dehydrogenase Type 3 Deficiency: an N-of-1 Study	PHASE3	UNKNOWN
The Role of Mineralocorticoid Receptors in Vascular Function	PHASE2/PHASE3	COMPLETED
Pharmacokinetics, Safety and Tolerability of Crinecerfont in Participants With Congenital Adrenal Hyperplasia Who Are Less Than 2 Years Old	PHASE2	ACTIVE_NOT_RECRUITING
Comparison of Two Forms of Hydrocortisone in Patients With Congenital Adrenal Hyperplasia	PHASE1/PHASE2	COMPLETED
Androgen Reduction in Congenital Adrenal Hyperplasia	PHASE2	WITHDRAWN
Apalutamide and Leuprolide in Intermediate and High-risk Prostate Cancer	PHASE2	COMPLETED
A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer	PHASE2	RECRUITING
A Study Examining Doses of Abiraterone Acetate in Adult Women With 21-Hydroxylase Deficiency	PHASE1	COMPLETED
Biomarkers in Bone Marrow and Blood Samples From Patients With Prostate Cancer Treated With Ketoconazole	nan	WITHDRAWN
Mutation Analysis of 17βhydroxysteroid Dehydrogenase 3 Deficiency	nan	UNKNOWN
Pattern of Gene Expression in Adipose Tissue From Patients With Cushing Syndrome	nan	COMPLETED
Polycystic Ovary Syndrome in Type 1 Diabetes	nan	NOT_YET_RECRUITING
Linear Growth of Children With Congenital Adrenal Hyperplasia	nan	UNKNOWN
Effect of Surgical or Conservative Approach in Patients With Adrenal Incidentalomas	nan	UNKNOWN
5-Alpha Reductase 2 as a Marker of Resistance to 5ARI Therapy	nan	RECRUITING
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension	nan	UNKNOWN
Final Height in Patients With CAH	nan	UNKNOWN
Determining the Long-Term Effects of Prenatal Dexamethasone Treatment in Children With 21-Hydroxylase Deficiency and Their Mothers	nan	UNKNOWN
Adrenal Function in GHD Children	nan	COMPLETED
Cortisol Regulation in Polycystic Ovary Syndrome (PCOS)	nan	COMPLETED
Fertility and Pregnancy in Patients With Classic Congenital Adrenal Hyperplasia	nan	COMPLETED
Novel Biomarker for Development of T2D	nan	COMPLETED
Examining Genetic Differences Among People With 21-Hydroxylase Deficiency	nan	COMPLETED
Adrenocortical Functions in Women With Nonclassical 21-hydroxylase Deficiency.	nan	UNKNOWN
Mutation Analysis of 17α-Hydroxylase	nan	UNKNOWN
Impact of 11-oxygenated Androgens on Metabolic Dysfunction of Women With Polycystic Ovary Syndrome	nan	UNKNOWN
Evaluating a Personalised Online Program With Human Support for Women With Depression and Its Impact on Mental Health and Biological Changes	nan	NOT_YET_RECRUITING
Hydrocortisone Modified-release in Adults: Real-world Monitoring of Longitudinal Outcomes in coNgenital Adrenal hYperplasia	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a HSD3B1 binder may also engage these)

Protein	Name	Similarity
Q64421	—	1.000	Q64421 →
HSD3B2	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2	0.999	landscape →
P27365	—	0.999	P27365 →
P24815	—	0.996	P24815 →
P26150	—	0.996	P26150 →
Q60555	—	0.994	Q60555 →
P22071	—	0.994	P22071 →
Q62878	—	0.993	Q62878 →
P14893	—	0.993	P14893 →
O35469	—	0.992	O35469 →
Q5IFP1	—	0.992	Q5IFP1 →
O46516	—	0.992	O46516 →
P26149	—	0.991	P26149 →
P22072	—	0.991	P22072 →
Q9N119	—	0.990	Q9N119 →
O35296	—	0.988	O35296 →
P27364	—	0.988	P27364 →
Q61767	—	0.985	Q61767 →
Q5PPL3	—	0.982	Q5PPL3 →
Q61694	—	0.981	Q61694 →
Q9R1J0	—	0.980	Q9R1J0 →
Q15738	—	0.977	Q15738 →
Q4R7R1	—	0.977	Q4R7R1 →
Q9D665	—	0.976	Q9D665 →
A8DZE7	—	0.974	A8DZE7 →
Q3ZBE9	—	0.971	Q3ZBE9 →
Q8WUS8	—	0.970	Q8WUS8 →
HSD17B7	3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7	0.969	landscape →
Q32L94	—	0.968	Q32L94 →
Q62904	—	0.968	Q62904 →