Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 16/20 | 0.40 |
| ▸ | JAK2 | O60674 | 13/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16245243 | 0.89 | JAK3 (0.42) | JAK3JAK2DGAT1 | |
| SCHEMBL15032744 | 0.83 | JAK3 (0.61) | JAK3 | |
| SCHEMBL15032835 | 0.78 | JAK3 (0.45) | JAK3JAK2 | |
| SCHEMBL15032721 | 0.77 | JAK3 (0.61) | JAK3JAK2DGAT1 | |
| SCHEMBL15013944 | 0.75 | ADK (0.39) | JAK3JAK2DGAT1NPC1ALDH1A1 | |
| SCHEMBL15032820 | 0.75 | PDE4A (0.42) | JAK3JAK2ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL15032625 | 0.75 | JAK3 (0.39) | JAK3JAK2DGAT1 | |
| SCHEMBL16245446 | 0.74 | JAK3 (0.38) | JAK3JAK2DGAT1 | |
| SCHEMBL15032947 | 0.73 | JAK3 (0.39) | JAK3JAK2DGAT1 | |
| SCHEMBL16245202 | 0.72 | JAK3 (0.37) | JAK3JAK2DGAT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013085802-A1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-06-13 | — | — | WO | disclosed |