SCHEMBL1503388

SCHEMBL1503388

O=C(NCC(c1ccccc1)n1ccnc1)c1ccc(-c2ccc(Cl)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP24A1 Q07973 19/20 1.00
CYP27B1 O15528 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8540395 1.00 CYP24A1 (1.00) CYP24A1CYP27B1
SCHEMBL1503385 1.00 CYP24A1 (1.00) CYP24A1CYP27B1
SCHEMBL7126449 0.97 CYP24A1 (0.94) CYP24A1CYP27B1
SCHEMBL7070181 0.87 CYP24A1 (0.77) CYP24A1CYP27B1
SCHEMBL7068187 0.83 CYP24A1 (0.70) CYP24A1CYP27B1
SCHEMBL7066367 0.82 CYP24A1 (0.69) CYP24A1CYP27B1
SCHEMBL28508110 0.81 CYP24A1 (0.72) CYP24A1CYP27B1
SCHEMBL7068036 0.79 CYP24A1 (0.74) CYP24A1CYP27B1
SCHEMBL7071390 0.79 CYP24A1 (0.74) CYP24A1CYP27B1
SCHEMBL7072584 0.79 CYP24A1 (0.74) CYP24A1CYP27B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2281058-B1 METHODS, COMPOSITIONS, USES, AND KITS USEFUL FOR VITAMIN D DEFICIENCY AND RELATED DISORDERS OPKO IRELAND GLOBAL HOLDINGS LTD (IE) 2016-06-29 EP claimed
CN-1060163-C Acylated aminoalknimidazoles and-triazoles NORVATIS (CH) 2001-01-03 CN claimed
EP-0683156-B1 Acylated aminoalkanimidazoles and -triazoles CIBA GEIGY AG (CH) 1998-04-01 EP claimed
US-5622982-A ENZYME INHIBITORS; ANTIINFLAMMATORY AGENTS SANDOZ LTD. (CH) 1997-04-22 US claimed
CN-1120039-A Acylated aminoalknimidazoles and-triazoles SANDOZ LTD (CH) 1996-04-10 CN claimed
EP-0683156-A1 Acylated aminoalkanimidazoles and -triazoles SANDOZ LTD. (CH) 1995-11-22 EP claimed
JP-8053422-A None JP disclosed
US-10302660-B2 Methods useful for vitamin D deficiency and related disorders OPKO RENAL, LLC (US) 2019-05-28 US disclosed
US-20170067917-A1 METHODS USEFUL FOR VITAMIN D DEFICIENCY AND RELATED DISORDERS EIRGEN PHARMA LTD. (IE) 2017-03-09 US disclosed
EP-3112476-A2 METHODS, COMPOSITIONS, USES, AND KITS USEFUL FOR VITAMIN D DEFICIENCY AND RELATED DISORDERS Opko Ireland Global Holdings, Ltd. (IE) 2017-01-04 EP disclosed
US-9500661-B2 Methods useful for vitamin D deficiency and related disorders OPKO RENAL, LLC (US) 2016-11-22 US disclosed
EP-2281058-B1 METHODS, COMPOSITIONS, USES, AND KITS USEFUL FOR VITAMIN D DEFICIENCY AND RELATED DISORDERS OPKO IRELAND GLOBAL HOLDINGS LTD (IE) 2016-06-29 EP disclosed
US-20150141385-A1 Methods Useful for Vitamin D Deficiency and Related Disorders EIRGEN PHARMA LTD. (IE) 2015-05-21 US disclosed
US-20090088373-A1 USE OF COMPOSITIONS TO ENHANCE INNATE IMMUNE RESPONSE BVR TECHNOLOGIES CO. 2009-04-02 US disclosed
CN-1060163-C Acylated aminoalknimidazoles and-triazoles NORVATIS (CH) 2001-01-03 CN disclosed
EP-0683156-B1 Acylated aminoalkanimidazoles and -triazoles CIBA GEIGY AG (CH) 1998-04-01 EP disclosed
US-5622982-A ENZYME INHIBITORS; ANTIINFLAMMATORY AGENTS SANDOZ LTD. (CH) 1997-04-22 US disclosed
CN-1120039-A Acylated aminoalknimidazoles and-triazoles SANDOZ LTD (CH) 1996-04-10 CN disclosed
JP-H0853422-A ACYLATED AMINOALKANEIMIDAZOLES AND TRIAZOLES SANDOZ AG 1996-02-27 JP disclosed
EP-0683156-A1 Acylated aminoalkanimidazoles and -triazoles SANDOZ LTD. (CH) 1995-11-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090088373-A1 USE OF COMPOSITIONS TO ENHANCE INNATE IMMUNE RESPONSE MYD88, MTOR, TLR3 CYP24A1 153/4885CYP27B1 739/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.