SCHEMBL8540395

SCHEMBL8540395

O=C(NC[C@H](c1ccccc1)n1ccnc1)c1ccc(-c2ccc(Cl)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP24A1 Q07973 19/20 1.00
CYP27B1 O15528 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1503385 1.00 CYP24A1 (1.00) CYP24A1CYP27B1
SCHEMBL1503388 1.00 CYP24A1 (1.00) CYP24A1CYP27B1
SCHEMBL7126449 0.97 CYP24A1 (0.94) CYP24A1CYP27B1
SCHEMBL7070181 0.87 CYP24A1 (0.77) CYP24A1CYP27B1
SCHEMBL7068187 0.83 CYP24A1 (0.70) CYP24A1CYP27B1
SCHEMBL7066367 0.82 CYP24A1 (0.69) CYP24A1CYP27B1
SCHEMBL28508110 0.81 CYP24A1 (0.72) CYP24A1CYP27B1
SCHEMBL7068036 0.79 CYP24A1 (0.74) CYP24A1CYP27B1
SCHEMBL7071390 0.79 CYP24A1 (0.74) CYP24A1CYP27B1
SCHEMBL7072584 0.79 CYP24A1 (0.74) CYP24A1CYP27B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0683156-B1 Acylated aminoalkanimidazoles and -triazoles CIBA GEIGY AG (CH) 1998-04-01 EP disclosed
US-5622982-A ENZYME INHIBITORS; ANTIINFLAMMATORY AGENTS SANDOZ LTD. (CH) 1997-04-22 US disclosed
EP-0683156-A1 Acylated aminoalkanimidazoles and -triazoles SANDOZ LTD. (CH) 1995-11-22 EP disclosed