Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10141564 | 0.88 | PDK2 (0.42) | ACHEALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL10080930 | 0.81 | CCNC (0.42) | BCHEACHELMNASMN1; SMN2MEN1 | |
| SCHEMBL24758392 | 0.80 | EP300 (0.35) | MEN1TSHRMAPK1KMT2A | |
| SCHEMBL22916887 | 0.80 | PDK2 (0.46) | ALDH1A1KDM4EHTTSMN1; SMN2POLB | |
| SCHEMBL24247167 | 0.78 | CCNC (0.40) | — | |
| SCHEMBL22305077 | 0.77 | MEN1 (0.46) | HTTLMNASMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL15462076 | 0.77 | ACHE (0.38) | ACHEALDH1A1SMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL19321624 | 0.77 | HTT (0.40) | ACHEALDH1A1HTTL3MBTL1MEN1 | |
| SCHEMBL22971645 | 0.76 | SYK (0.42) | ACHEALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL15592363 | 0.76 | KMT2A (0.43) | ALDH1A1KDM4ESMN1; SMN2MEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466288-B2 | Isoindolinone inhibitors of phosphatidylinositol 3-kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-06-18 | — | — | US | disclosed |