Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1503642 | 1.00 | ADAM17 (0.53) | ADAM17TP53ATMLMNAMAPT | |
| SCHEMBL10475892 | 0.92 | ADAM17 (0.53) | ADAM17TP53ATMLMNAMAPT | |
| SCHEMBL10475894 | 0.92 | ADAM17 (0.53) | ADAM17TP53ATMLMNAMAPT | |
| SCHEMBL1503620 | 0.90 | ADAM17 (0.55) | ADAM17TP53LMNAMAPTALDH1A1 | |
| SCHEMBL1503675 | 0.90 | ADAM17 (0.55) | ADAM17TP53LMNAMAPTALDH1A1 | |
| SCHEMBL1504730 | 0.88 | ADAM17 (0.44) | ADAM17TP53ALDH1A1CTNNB1 | |
| SCHEMBL1504686 | 0.85 | ADAM17 (0.62) | ADAM17ALDH1A1 | |
| SCHEMBL1504782 | 0.85 | ADAM17 (0.62) | ADAM17ALDH1A1 | |
| SCHEMBL1504822 | 0.84 | ADAM17 (0.51) | ADAM17TP53 | |
| SCHEMBL1503533 | 0.82 | TP53 (0.53) | ADAM17TP53ATMLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033010-A1 | 4-ALKOXY-N- (2-HYDROXYCARBAMOYL-2-PIPERIDINYL-ETHYL) -BENZAMIDE COMPOUNDS AS SELECTIVE TACE-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-03-24 | — | — | WO | disclosed |