Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 6/20 | 0.34 |
| ▸ | NOD2 | Q9HC29 | 6/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.34 |
| ▸ | CDK4 | P11802 | 5/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.33 |
| ▸ | CCND1 | P24385 | 4/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15036145 | 0.80 | CDK4 (0.34) | RIPK2NOD2ACVR1CDK4FGFR1 | |
| SCHEMBL15034858 | 0.80 | CDK4 (0.37) | CDK4FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL15034969 | 0.78 | CDK4 (0.37) | CDK4FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL15035852 | 0.78 | TNK2 (0.36) | RIPK2NOD2ACVR1CDK4FGFR1 | |
| SCHEMBL15035871 | 0.78 | CSF1R (0.35) | RIPK2NOD2ACVR1CDK4FGFR1 | |
| SCHEMBL15041701 | 0.73 | SRC (0.38) | RIPK2NOD2ACVR1CDK4FGFR1 | |
| SCHEMBL15035335 | 0.72 | CDK4 (0.39) | CDK4FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL15035400 | 0.71 | CDK4 (0.36) | CDK4FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL16309176 | 0.71 | TNK2 (0.40) | RIPK2NOD2ACVR1CDK4FGFR1 | |
| SCHEMBL15036027 | 0.70 | CDK9 (0.36) | CDK4FGFR1FGFR2FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130252967-A1 | 8-(SULFONYLBENZYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | AFRAXIS, INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20130252967-A1 | 8-(SULFONYLBENZYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | AFRAXIS, INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252967-A1 | 8-(SULFONYLBENZYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | PAK2, PAK3, PAK6 | RIPK2 1162/4885NOD2 4034/4885ACVR1 4860/4885 |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | RIPK2 971/4885NOD2 4628/4885ACVR1 4752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.