SCHEMBL1503578

SCHEMBL1503578

CC(Oc1ccc(C(=O)NC[C@@H](C(=O)NO)N2CCSCC2)cc1)C1CCNCC1

nearest known ligand 0.50

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ADAM17 P78536 20/20 0.50
ADAM10 O14672 3/20 0.46
MMP3 P08254 2/20 0.46
ADAM9 Q13443 1/20 0.45
MMP1 P03956 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15327690 1.00 ADAM17 (0.50) ADAM17ADAM10MMP3ADAM9MMP1
SCHEMBL10276911 0.86 ADAM17 (0.58) ADAM17ADAM10MMP3ADAM9MMP1
SCHEMBL12077084 0.77 ADAM17 (0.67) ADAM17ADAM10MMP3ADAM9MMP1
SCHEMBL12077080 0.77 ADAM17 (0.67) ADAM17ADAM10MMP3ADAM9MMP1
SCHEMBL17019809 0.73 ADAM17 (0.53) ADAM17ADAM10MMP3ADAM9MMP1
SCHEMBL10276389 0.70 ADAM17 (0.62) ADAM17ADAM10MMP3ADAM9MMP1
SCHEMBL15327676 0.70 ADAM17 (0.62) ADAM17ADAM10MMP3ADAM9MMP1
SCHEMBL15936257 0.70 ADAM17 (0.58) ADAM17MMP3ADAM9MMP1
SCHEMBL1503560 0.69 ADAM17 (0.85) ADAM17ADAM10MMP3ADAM9MMP1
SCHEMBL1503563 0.69 ADAM17 (0.85) ADAM17ADAM10MMP3ADAM9MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2477969-A1 4-ALKOXY-N- (2-HYDROXYCARBAMOYL-2-PIPERIDINYL-ETHYL) -BENZAMIDE COMPOUNDS AS SELECTIVE TACE-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES Galderma Research & Development (FR) 2012-07-25 EP claimed
WO-2011033010-A1 4-ALKOXY-N- (2-HYDROXYCARBAMOYL-2-PIPERIDINYL-ETHYL) -BENZAMIDE COMPOUNDS AS SELECTIVE TACE-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES GALDERMA RESEARCH & DEVELOPMENT (FR) 2011-03-24 WO claimed
EP-2477969-A1 4-ALKOXY-N- (2-HYDROXYCARBAMOYL-2-PIPERIDINYL-ETHYL) -BENZAMIDE COMPOUNDS AS SELECTIVE TACE-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES Galderma Research & Development (FR) 2012-07-25 EP disclosed
WO-2011033010-A1 4-ALKOXY-N- (2-HYDROXYCARBAMOYL-2-PIPERIDINYL-ETHYL) -BENZAMIDE COMPOUNDS AS SELECTIVE TACE-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES GALDERMA RESEARCH & DEVELOPMENT (FR) 2011-03-24 WO disclosed