Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.35 |
| ▸ | STAT6 | P42226 | 1/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 8/20 | 0.35 |
| ▸ | SRC | P12931 | 3/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | WEE1 | P30291 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15041847 | 0.94 | PTK2 (0.42) | PTK2JAK3PAK4PKN1STAT6 | |
| SCHEMBL15035782 | 0.78 | PTK2 (0.38) | PTK2JAK3PAK4PKN1STAT6 | |
| SCHEMBL15034889 | 0.76 | JAK3 (0.39) | PTK2JAK3PAK4PKN1STAT6 | |
| SCHEMBL15035647 | 0.76 | JAK3 (0.39) | PTK2JAK3PAK4PKN1STAT6 | |
| SCHEMBL15035796 | 0.75 | TNK2 (0.37) | JAK3TNK2SRC | |
| SCHEMBL15035816 | 0.74 | CAMK2D (0.35) | JAK3TNK2SRCACVR1 | |
| SCHEMBL15035884 | 0.73 | CAMK2D (0.37) | PTK2JAK3TNK2SRC | |
| SCHEMBL15035926 | 0.73 | PTK2 (0.45) | PTK2JAK3PAK4PKN1TNK2 | |
| SCHEMBL15035668 | 0.72 | JAK3 (0.35) | PTK2JAK3TNK2SRC | |
| SCHEMBL15041415 | 0.72 | PTK2 (0.39) | PTK2JAK3PAK4PKN1STAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130252967-A1 | 8-(SULFONYLBENZYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | AFRAXIS, INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252967-A1 | 8-(SULFONYLBENZYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | PAK2, PAK3, PAK6 | PTK2 166/4885JAK3 525/4885PAK4 5/4885 |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | PTK2 12/4885JAK3 1901/4885PAK4 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.