Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 8/20 | 0.52 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.51 |
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1503633 | 1.00 | ADAM17 (0.52) | ADAM17ADAM10MMP3SLC6A2SLC6A3 | |
| SCHEMBL1503533 | 0.88 | TP53 (0.53) | ADAM17LMNATP53MAPTALDH1A1 | |
| SCHEMBL1503539 | 0.88 | TP53 (0.53) | ADAM17LMNATP53MAPTALDH1A1 | |
| SCHEMBL10475831 | 0.85 | ADAM17 (0.51) | ADAM17ADAM10MMP3SLC6A2SLC6A3 | |
| SCHEMBL10475888 | 0.85 | ADAM17 (0.51) | ADAM17ADAM10MMP3SLC6A2SLC6A3 | |
| SCHEMBL1504948 | 0.84 | ADAM17 (0.66) | ADAM17ADAM10MMP3MAPTMMP1 | |
| SCHEMBL1504679 | 0.84 | ADAM17 (0.66) | ADAM17ADAM10MMP3MAPTMMP1 | |
| SCHEMBL1503675 | 0.82 | ADAM17 (0.55) | ADAM17ADAM10MMP3LMNATP53 | |
| SCHEMBL1503620 | 0.82 | ADAM17 (0.55) | ADAM17ADAM10MMP3LMNATP53 | |
| SCHEMBL1503641 | 0.81 | ADAM17 (0.79) | ADAM17ADAM10MMP3LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033010-A1 | 4-ALKOXY-N- (2-HYDROXYCARBAMOYL-2-PIPERIDINYL-ETHYL) -BENZAMIDE COMPOUNDS AS SELECTIVE TACE-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-03-24 | — | — | WO | disclosed |