Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 20/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.66 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15036965 | 0.90 | KCNJ1 (0.54) | KCNJ1KCNH2 | |
| SCHEMBL15036650 | 0.89 | KCNJ1 (0.66) | KCNJ1KCNH2 | |
| SCHEMBL15036645 | 0.89 | KCNJ1 (0.66) | KCNJ1KCNH2 | |
| SCHEMBL15036853 | 0.85 | KCNJ1 (0.58) | KCNJ1KCNH2 | |
| SCHEMBL15036646 | 0.82 | KCNJ1 (0.69) | KCNJ1KCNH2 | |
| SCHEMBL15036644 | 0.82 | KCNJ1 (0.69) | KCNJ1KCNH2 | |
| SCHEMBL15036958 | 0.81 | KCNJ1 (0.87) | KCNJ1KCNH2SSTR2 | |
| SCHEMBL16227698 | 0.81 | KCNJ1 (0.87) | KCNJ1KCNH2SSTR2 | |
| SCHEMBL15036815 | 0.79 | KCNJ1 (1.00) | KCNJ1KCNH2SSTR2 | |
| SCHEMBL15036851 | 0.79 | KCNJ1 (1.00) | KCNJ1KCNH2SSTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013090271-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2013-06-20 | — | — | WO | disclosed |