Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.69 |
| ▸ | MAOB | P27338 | 2/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | MME | P08473 | 5/20 | 0.42 |
| ▸ | ACE | P12821 | 3/20 | 0.42 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14303415 | 0.88 | TAAR1 (0.53) | TAAR1MAOBALOX5 | |
| SCHEMBL31491189 | 0.82 | TAAR1 (0.71) | TAAR1MAOBALOX5ESR2PGR | |
| SCHEMBL16394285 | 0.82 | TAAR1 (0.71) | TAAR1MAOBALOX5ESR2PGR | |
| SCHEMBL2690730 | 0.82 | TAAR1 (1.00) | TAAR1MAOBALOX5ESR2BACE1 | |
| SCHEMBL20669453 | 0.80 | TAAR1 (0.68) | TAAR1MAOBALOX5ESR2PGR | |
| SCHEMBL1623905 | 0.80 | TAAR1 (0.69) | TAAR1MAOBALOX5ESR2GRM2 | |
| Hydrochloric Acid SCHEMBL28279881 | 0.80 | TAAR1 (0.96) | TAAR1MAOBALOX5ESR2 | |
| SCHEMBL27900256 | 0.80 | TAAR1 (0.69) | TAAR1MAOBALOX5ESR2GRM2 | |
| SCHEMBL17432938 | 0.78 | MAOB (0.52) | TAAR1MAOBALOX5 | |
| SCHEMBL1520884 | 0.78 | TAAR1 (0.65) | TAAR1MAOBALOX5ESR2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2604269-B1 | 1,4-benzodiazepine-2,5-diones with therapeutic properties | UNIV MICHIGAN (US) | 2014-09-24 | — | — | EP | disclosed |
| EP-2604269-A1 | 1,4-benzodiazepine-2,5-diones with therapeutic properties | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-06-19 | — | — | EP | disclosed |