Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | CTSB | P07858 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1503748 | 1.00 | AKT1 (0.43) | AKT1EPHX2KMT2AL3MBTL1CTSD | |
| SCHEMBL1503893 | 1.00 | AKT1 (0.43) | AKT1EPHX2KMT2AL3MBTL1CTSD | |
| SCHEMBL1503750 | 1.00 | AKT1 (0.43) | AKT1EPHX2KMT2AL3MBTL1CTSD | |
| SCHEMBL1503868 | 0.85 | KMT2A (0.45) | AKT1EPHX2KMT2AL3MBTL1CTSD | |
| SCHEMBL1503870 | 0.85 | KMT2A (0.45) | AKT1EPHX2KMT2AL3MBTL1CTSD | |
| SCHEMBL1504083 | 0.85 | KMT2A (0.45) | AKT1EPHX2KMT2AL3MBTL1CTSD | |
| SCHEMBL1504079 | 0.85 | KMT2A (0.45) | AKT1EPHX2KMT2AL3MBTL1CTSD | |
| SCHEMBL1503767 | 0.80 | AKT1 (0.43) | AKT1KMT2AL3MBTL1NFKB1NFKB2 | |
| SCHEMBL4264989 | 0.79 | NAAA (0.48) | EPHX2KMT2AL3MBTL1CTSL | |
| SCHEMBL4261289 | 0.79 | NAAA (0.48) | EPHX2KMT2AL3MBTL1CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343290-A1 | Diamine derivatives as factor X inhibitors | Daiichi Sankyo Company, Limited (JP) | 2011-07-13 | — | — | EP | disclosed |
| US-20110077266-A1 | Diamine Derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-03-31 | — | — | US | disclosed |
| US-20100093785-A1 | DIAMINE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2010-04-15 | — | — | US | disclosed |
| US-20050119486-A1 | Diamine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2005-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093785-A1 | DIAMINE DERIVATIVES | C9, C1S, C1R | AKT1 3451/4885EPHX2 2815/4885KMT2A 3179/4885 |
| US-20050119486-A1 | Diamine derivatives | C9, C1S, C1R | AKT1 3643/4885EPHX2 3356/4885KMT2A 3485/4885 |
| US-20110077266-A1 | Diamine Derivatives | F2, TFPI, F3 | AKT1 3549/4885EPHX2 482/4885KMT2A 1453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.