Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16291892 | 1.00 | NTRK1 (0.52) | NTRK1JAK2 | |
| SCHEMBL15017227 | 0.92 | NTRK1 (0.54) | NTRK1JAK2 | |
| SCHEMBL15017228 | 0.92 | NTRK1 (0.54) | NTRK1JAK2 | |
| SCHEMBL16292929 | 0.90 | NTRK1 (0.51) | NTRK1JAK2 | |
| SCHEMBL15039640 | 0.90 | NTRK1 (0.51) | NTRK1JAK2 | |
| SCHEMBL15017226 | 0.88 | NTRK1 (0.55) | NTRK1JAK2 | |
| SCHEMBL15017225 | 0.88 | NTRK1 (0.55) | NTRK1JAK2 | |
| SCHEMBL15017028 | 0.87 | NTRK1 (0.50) | NTRK1JAK2 | |
| SCHEMBL15017031 | 0.87 | NTRK1 (0.50) | NTRK1JAK2 | |
| SCHEMBL15039639 | 0.87 | NTRK1 (0.51) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180354951-A1 | Substituted Pyrazolo[1,5-a] Pyridine As Tropomyosin Receptor Kinase (trk) Inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2018-12-13 | — | — | US | claimed |
| EP-2791138-B1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS | Dr Reddys Laboratories Ltd (IN) | 2018-06-06 | — | — | EP | claimed |
| US-20170267677-A1 | SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2017-09-21 | — | — | US | claimed |
| US-9402833-B2 | Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2016-08-02 | — | — | US | claimed |
| US-20150258076-A1 | SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2015-09-17 | — | — | US | claimed |
| US-9045478-B2 | Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2015-06-02 | — | — | US | claimed |
| US-20140371217-A1 | SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2014-12-18 | — | — | US | claimed |
| US-10344031-B2 | Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2019-07-09 | — | — | US | disclosed |
| US-10344031-B2 | Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2019-07-09 | — | — | US | disclosed |
| US-20180354951-A1 | Substituted Pyrazolo[1,5-a] Pyridine As Tropomyosin Receptor Kinase (trk) Inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2018-12-13 | — | — | US | disclosed |
| EP-2791138-B1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS | Dr Reddys Laboratories Ltd (IN) | 2018-06-06 | — | — | EP | disclosed |
| EP-2791138-B1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS | Dr Reddys Laboratories Ltd (IN) | 2018-06-06 | — | — | EP | disclosed |
| US-20170267677-A1 | SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2017-09-21 | — | — | US | disclosed |
| US-9045478-B2 | Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2015-06-02 | — | — | US | disclosed |
| US-9045478-B2 | Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2015-06-02 | — | — | US | disclosed |
| US-9045478-B2 | Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2015-06-02 | — | — | US | disclosed |
| US-20140371217-A1 | SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2014-12-18 | — | — | US | disclosed |
| US-20140371217-A1 | SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2014-12-18 | — | — | US | disclosed |
| US-20140371217-A1 | SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2014-12-18 | — | — | US | disclosed |
| WO-2013088256-A1 | SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2013-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180354951-A1 | Substituted Pyrazolo[1,5-a] Pyridine As Tropomyosin Receptor Kinase (trk) Inhibitors | MUSK, DMPK, PNCK | NTRK1 4/4885JAK2 700/4885 |
| US-20150258076-A1 | SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS | MUSK, DMPK, PNCK | NTRK1 4/4885JAK2 700/4885 |
| US-10344031-B2 | Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors | MUSK, DMPK, PNCK | NTRK1 4/4885JAK2 700/4885 |
| US-20170267677-A1 | SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS | MUSK, DMPK, PNCK | NTRK1 4/4885JAK2 700/4885 |
| US-20140371217-A1 | SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS | MUSK, DMPK, PNCK | NTRK1 4/4885JAK2 700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.