Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 12/20 | 0.41 |
| ▸ | CCND1 | P24385 | 11/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.39 |
| ▸ | CDK2 | P24941 | 8/20 | 0.39 |
| ▸ | CCND2 | P30279 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15035332 | 0.93 | CDK4 (0.41) | CDK4CCND1FGFR1FGFR2FGFR4 | |
| SCHEMBL15041311 | 0.86 | CDK4 (0.40) | CDK4CCND1FGFR1FGFR2FGFR4 | |
| SCHEMBL15041308 | 0.85 | MAPK14 (0.40) | CDK4CCND1FGFR1FGFR2FGFR4 | |
| SCHEMBL15041774 | 0.80 | MAPK14 (0.41) | CDK4CCND1FGFR1FGFR2FGFR4 | |
| SCHEMBL15035428 | 0.79 | CDK4 (0.41) | CDK4CCND1FGFR1FGFR2FGFR4 | |
| SCHEMBL15041342 | 0.79 | MAPK14 (0.40) | CDK4CCND1FGFR1FGFR2FGFR4 | |
| SCHEMBL15041830 | 0.78 | RIPK2 (0.45) | CDK4CCND1MAPK14MAPK8 | |
| SCHEMBL15035313 | 0.78 | CDK4 (0.39) | CDK4CCND1FGFR1FGFR2FGFR4 | |
| SCHEMBL15041603 | 0.77 | MAPK14 (0.39) | CDK4CCND1FGFR1FGFR2FGFR4 | |
| SCHEMBL15041408 | 0.77 | MAPK8 (0.40) | CDK4CCND1FGFR1FGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | CDK4 404/4885CCND1 2153/4885FGFR1 1919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.