Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 5/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 4/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.39 |
| ▸ | CDK4 | P11802 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | CASP7 | P55210 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15041774 | 0.85 | MAPK14 (0.41) | MAPK8MAPK14CDK4CCND1MAPK1 | |
| SCHEMBL15041629 | 0.84 | MAPK14 (0.38) | MAPK8MAPK14CDK4MAPK1 | |
| SCHEMBL15041342 | 0.84 | MAPK14 (0.40) | MAPK8MAPK14CDK4CCND1PTK2 | |
| SCHEMBL15041603 | 0.82 | MAPK14 (0.39) | MAPK8MAPK14CDK4CCND1 | |
| SCHEMBL15041408 | 0.82 | MAPK8 (0.40) | MAPK8MAPK14CDK4CCND1 | |
| SCHEMBL15041553 | 0.78 | CDK4 (0.41) | MAPK8MAPK14CDK4CCND1 | |
| SCHEMBL15041835 | 0.78 | PTK2 (0.42) | MAPK8MAPK14CDK4PTK2 | |
| SCHEMBL15035023 | 0.78 | CDK4 (0.38) | MAPK8CDK4USP2CYP3A4CYP2C9 | |
| SCHEMBL15035883 | 0.77 | CDK4 (0.37) | MAPK8MAPK14CDK4CCND1PTK2 | |
| SCHEMBL15034799 | 0.77 | CDK4 (0.36) | MAPK8CDK4CCND1PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130252967-A1 | 8-(SULFONYLBENZYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | AFRAXIS, INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252967-A1 | 8-(SULFONYLBENZYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | PAK2, PAK3, PAK6 | RIPK2 1162/4885NOD2 4034/4885ACVR1 4860/4885 |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | RIPK2 971/4885NOD2 4628/4885ACVR1 4752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.