Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK3 | O75914 | 3/20 | 0.35 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.35 |
| ▸ | PAK2 | Q13177 | 3/20 | 0.35 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 6/20 | 0.35 |
| ▸ | NOD2 | Q9HC29 | 5/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.35 |
| ▸ | STK4 | Q13043 | 1/20 | 0.34 |
| ▸ | STK3 | Q13188 | 1/20 | 0.34 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.34 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.34 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 3/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.33 |
| ▸ | CCND1 | P24385 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15036108 | 0.85 | PAK1 (0.39) | PAK3PAK1PAK2PKN1FGFR1 | |
| SCHEMBL15036073 | 0.79 | CDK4 (0.43) | FGFR1CDK4CCNA2CCND1CDK2 | |
| SCHEMBL15041890 | 0.78 | TNK2 (0.40) | PAK3PAK1PAK2PKN1RIPK2 | |
| SCHEMBL15036019 | 0.78 | JAK2 (0.43) | PKN1FGFR1PAK4CDK4FGFR4 | |
| SCHEMBL13553935 | 0.77 | TNK2 (0.38) | PAK3PAK1PAK2PKN1RIPK2 | |
| SCHEMBL15281043 | 0.74 | CAMK2D (0.44) | PAK3PAK1PAK2PKN1RIPK2 | |
| SCHEMBL15036149 | 0.73 | TNK2 (0.41) | PAK3PAK1PAK2PKN1RIPK2 | |
| SCHEMBL15041661 | 0.73 | PTK2 (0.44) | — | |
| SCHEMBL15041439 | 0.73 | RIPK2 (0.42) | RIPK2NOD2ACVR1FGFR1CDK4 | |
| SCHEMBL15041524 | 0.72 | RIPK2 (0.42) | PAK3PAK1PAK2PKN1RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912203-B2 | 6-(sulfonylaryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS HOLDINGS, INC. (US) | 2014-12-16 | — | — | US | disclosed |
| US-20130252966-A1 | 6-(SULFONYLARYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | AFRAXIS, INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252966-A1 | 6-(SULFONYLARYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | PAK2, PAK6, PAK3 | PAK3 3/4885PAK1 6/4885PAK2 1/4885 |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | PAK3 6/4885PAK1 4/4885PAK2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.