Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 4/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 4/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 6/20 | 0.35 |
| ▸ | USP2 | O75604 | 6/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.35 |
| ▸ | CASP1 | P29466 | 5/20 | 0.35 |
| ▸ | CASP7 | P55210 | 5/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15036248 | 0.89 | RIPK2 (0.35) | RIPK2ACVR1NOD2TNK2MEN1 | |
| SCHEMBL15041604 | 0.84 | CDK4 (0.33) | RIPK2ACVR1NOD2MEN1USP2 | |
| SCHEMBL15617465 | 0.78 | CDK4 (0.39) | RIPK2ACVR1NOD2KDM1ARCOR1 | |
| SCHEMBL15036208 | 0.77 | TNK2 (0.39) | TNK2CDK4CCND1CCNA2CDK2 | |
| SCHEMBL15036172 | 0.77 | CDK4 (0.37) | CDK4CCND1CCNA2CDK2FLT3 | |
| SCHEMBL15036478 | 0.76 | CDK4 (0.37) | RIPK2ACVR1NOD2MEN1USP2 | |
| SCHEMBL15036339 | 0.76 | KDM1A (0.36) | RIPK2ACVR1NOD2CHEK1KDM1A | |
| SCHEMBL15035006 | 0.76 | CHEK1 (0.41) | TNK2CHEK1CDK4CCND1CCNA2 | |
| SCHEMBL15036331 | 0.75 | CDK4 (0.38) | RIPK2ACVR1NOD2TNK2KDM1A | |
| SCHEMBL15618052 | 0.75 | CHEK1 (0.34) | MEN1USP2KMT2ACYP1A2CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680099-B2 | 6-(ethynyl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS HOLDINGS, INC. (US) | 2014-03-25 | — | — | US | disclosed |
| US-8680099-B2 | 6-(ethynyl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS HOLDINGS, INC. (US) | 2014-03-25 | — | — | US | disclosed |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | RIPK2 971/4885ACVR1 4752/4885NOD2 4628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.