Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.34 |
| ▸ | CDK4 | P11802 | 9/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.34 |
| ▸ | CCND1 | P24385 | 7/20 | 0.34 |
| ▸ | CDK2 | P24941 | 7/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15041604 | 0.89 | CDK4 (0.33) | CHEK1CDK4FGFR1CCNA2CCND1 | |
| SCHEMBL15258290 | 0.86 | CDK4 (0.33) | CHEK1CDK4FGFR1CCNA2CCND1 | |
| SCHEMBL15618063 | 0.82 | FLT3 (0.40) | CHEK1CDK4FGFR1CCNA2CCND1 | |
| SCHEMBL15041893 | 0.82 | FLT3 (0.37) | CHEK1CDK4FGFR1CCNA2CCND1 | |
| SCHEMBL15036350 | 0.76 | CHEK1 (0.35) | CHEK1CDK4FGFR1CCNA2CCND1 | |
| SCHEMBL15617439 | 0.76 | CDK4 (0.37) | CDK4FGFR1CCNA2CCND1CDK2 | |
| SCHEMBL15041900 | 0.76 | CDK4 (0.36) | CDK4FGFR1CCNA2CCND1CDK2 | |
| SCHEMBL15036421 | 0.76 | CDK4 (0.32) | CDK4FGFR1CCNA2CCND1CDK2 | |
| SCHEMBL15036218 | 0.76 | AXL (0.35) | CHEK1CDK4FGFR1CCNA2CCND1 | |
| SCHEMBL15258255 | 0.76 | RIPK2 (0.35) | CHEK1CDK4FGFR1CCNA2CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680099-B2 | 6-(ethynyl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS HOLDINGS, INC. (US) | 2014-03-25 | — | — | US | disclosed |