Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.37 |
| ▸ | CDK4 | P11802 | 9/20 | 0.35 |
| ▸ | CCND1 | P24385 | 9/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.35 |
| ▸ | CDK2 | P24941 | 7/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | CCND2 | P30279 | 2/20 | 0.33 |
| ▸ | CCND3 | P30281 | 2/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15618063 | 0.93 | FLT3 (0.40) | FLT3CDK4CCND1CCNA2CDK2 | |
| SCHEMBL15036313 | 0.87 | FLT3 (0.35) | FLT3CDK4CCND1CCNA2CDK2 | |
| SCHEMBL15618052 | 0.82 | CHEK1 (0.34) | FLT3CDK4CCND1CCNA2CDK2 | |
| SCHEMBL15036447 | 0.79 | CDK4 (0.39) | FLT3CDK4CCND1CCNA2CDK2 | |
| SCHEMBL15041727 | 0.77 | BTK (0.35) | CDK4CCND1CCNA2CDK2FGFR1 | |
| SCHEMBL15259461 | 0.77 | PTK2 (0.37) | FLT3CDK4CCND1CCNA2CDK2 | |
| SCHEMBL15041900 | 0.76 | CDK4 (0.36) | FLT3CDK4CCND1CCNA2CDK2 | |
| SCHEMBL15041895 | 0.75 | FGFR1 (0.36) | FLT3CDK4CCND1CCNA2CDK2 | |
| SCHEMBL15258276 | 0.75 | CDK4 (0.35) | CDK4CCND1CCNA2CDK2FGFR1 | |
| SCHEMBL15036480 | 0.75 | AXL (0.40) | CDK4CCND1CCNA2CDK2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130245012-A1 | 6-(ETHYNYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | AFRAXIS, INC. (US) | 2013-09-19 | — | — | US | disclosed |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130245012-A1 | 6-(ETHYNYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | PAK2, PAK6, PAK3 | FLT3 661/4885CDK4 397/4885CCND1 3936/4885 |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | FLT3 811/4885CDK4 404/4885CCND1 2153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.