Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN4 | Q9Y3Q4 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15043264 | 0.93 | HCN4 (0.35) | HCN4CHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL15047171 | 0.83 | HCN4 (0.56) | HCN4CHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL15180368 | 0.81 | HCN4 (0.42) | HCN4CHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL15044202 | 0.79 | HCN4 (0.39) | HCN4CHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL12462421 | 0.78 | SMN1; SMN2 (0.40) | HCN4CHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL8360852 | 0.78 | HCN4 (0.40) | HCN4CHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL2443618 | 0.76 | SMN1; SMN2 (0.56) | HCN4CHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL8270902 | 0.76 | HCN4 (0.35) | HCN4CHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL8373923 | 0.76 | KMT2A (0.36) | HCN4CHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL15044209 | 0.74 | BRD4 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8513410-B2 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | LES LABORATOIRES SERVIER (FR) | 2013-08-20 | — | — | US | disclosed |
| US-20130158256-A1 | PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID | LES LABORATOIRES SERVIER (FR) | 2013-06-20 | — | — | US | disclosed |