SCHEMBL1504664

SCHEMBL1504664

CCCCOC(=O)NC(C)C(N)C(=O)O

nearest known ligand 0.44

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.42
NPC1 O15118 3/20 0.42
RAB9A P51151 3/20 0.42
HPGD P15428 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
EPHX1 P07099 1/20 0.42
ACHE P22303 7/20 0.41
ALDH1A1 P00352 1/20 0.40
CTSK P43235 1/20 0.39
MAPK1 P28482 1/20 0.38
ATM Q13315 1/20 0.38
NOD1 Q9Y239 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8216997 0.81 EPHX1 (0.48) SMN1; SMN2NPC1RAB9AHPGDL3MBTL1
SCHEMBL6033535 0.81 EPHX1 (0.48) SMN1; SMN2NPC1RAB9AHPGDL3MBTL1
SCHEMBL38661176 0.80 EPHX1 (0.47) SMN1; SMN2NPC1RAB9AHPGDL3MBTL1
SCHEMBL476725 0.80 EPHX1 (0.47) SMN1; SMN2NPC1RAB9AHPGDL3MBTL1
SCHEMBL459573 0.80 EPHX1 (0.47) SMN1; SMN2NPC1RAB9AHPGDL3MBTL1
SCHEMBL459574 0.80 EPHX1 (0.47) SMN1; SMN2NPC1RAB9AHPGDL3MBTL1
SCHEMBL2025412 0.79 SMN1; SMN2 (0.43) SMN1; SMN2NPC1RAB9AHPGDL3MBTL1
Hydrochloric Acid SCHEMBL10476064 0.78 EPHX1 (0.46) SMN1; SMN2NPC1RAB9AHPGDL3MBTL1
Threonine SCHEMBL1582519 0.78 ACE (0.40) SMN1; SMN2NPC1RAB9AHPGDL3MBTL1
SCHEMBL7416590 0.78 EPHX1 (0.48) SMN1; SMN2NPC1RAB9AHPGDL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011033009-A1 N- [2-HYDROXYCARBAMOYL-2- (PIPERAZINYL) ETHYL] BENZAMIDE COMPOUNDS, THEIR PREPARATION AND THEIR USE AS TACE INHIBITORS GALDERMA RESEARCH & DEVELOPMENT (FR) 2011-03-24 WO disclosed