Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.55 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2722765 | 0.78 | HCAR2 (0.67) | HCAR2MYCCYP11B2CYP11B1PTGS1 | |
| SCHEMBL21367480 | 0.78 | HCAR2 (0.50) | HCAR2MYCIDO1HDAC1HDAC6 | |
| SCHEMBL17321843 | 0.76 | HCAR2 (0.57) | HCAR2PTGS2 | |
| SCHEMBL27047722 | 0.75 | HCAR2 (0.52) | HCAR2MYCCYP11B2CYP11B1ABL1 | |
| SCHEMBL14395820 | 0.75 | HCAR2 (0.52) | HCAR2MYCCYP11B2CYP11B1ABL1 | |
| SCHEMBL27047697 | 0.75 | HCAR2 (0.52) | HCAR2MYCCYP11B2CYP11B1ABL1 | |
| SCHEMBL19144514 | 0.75 | HCAR2 (0.47) | HCAR2HDAC1HDAC6 | |
| SCHEMBL747240 | 0.74 | POLB (0.55) | HCAR2 | |
| SCHEMBL573416 | 0.74 | LMNA (0.55) | HCAR2 | |
| SCHEMBL5700309 | 0.74 | HCAR2 (0.32) | HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023240084-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | DENALI THERAPEUTICS INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| EP-2614825-A1 | Process for the preparation of thiazole derivatives | Dow AgroSciences LLC (US) | 2013-07-17 | — | — | EP | disclosed |
| EP-2604267-A1 | Process for the preparation of thiazole derivatives | Dow AgroSciences LLC (US) | 2013-06-19 | — | — | EP | disclosed |