Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 16/20 | 0.82 |
| ▸ | ADAM10 | O14672 | 3/20 | 0.54 |
| ▸ | MMP3 | P08254 | 3/20 | 0.54 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.54 |
| ▸ | MMP1 | P03956 | 1/20 | 0.51 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10276025 | 0.92 | ADAM17 (0.84) | ADAM17ADAM10MMP3ADAM9MMP1 | |
| SCHEMBL1504700 | 0.91 | ADAM17 (0.82) | ADAM17ADAM10MMP3ADAM9MMP1 | |
| SCHEMBL1504937 | 0.91 | ADAM17 (0.83) | ADAM17ADAM10MMP3ADAM9MMP1 | |
| SCHEMBL1504117 | 0.90 | ADAM17 (1.00) | ADAM17ADAM10MMP3ADAM9MMP1 | |
| SCHEMBL1504973 | 0.90 | ADAM17 (0.82) | ADAM17ADAM10MMP3ADAM9MMP1 | |
| SCHEMBL1504775 | 0.89 | ADAM17 (0.81) | ADAM17ADAM10MMP3ADAM9MMP1 | |
| SCHEMBL1504741 | 0.84 | ADAM17 (0.83) | ADAM17ADAM10MMP3ADAM9MMP1 | |
| SCHEMBL1504810 | 0.83 | ADAM17 (0.83) | ADAM17ADAM10MMP3ADAM9MMP1 | |
| SCHEMBL1504644 | 0.82 | ADAM17 (1.00) | ADAM17ADAM10MMP3ADAM9MMP1 | |
| SCHEMBL1504875 | 0.82 | ADAM17 (0.83) | ADAM17ADAM10MMP3ADAM9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033009-A1 | N- [2-HYDROXYCARBAMOYL-2- (PIPERAZINYL) ETHYL] BENZAMIDE COMPOUNDS, THEIR PREPARATION AND THEIR USE AS TACE INHIBITORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-03-24 | — | — | WO | disclosed |