Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 8/20 | 0.48 |
| ▸ | INSR | P06213 | 5/20 | 0.48 |
| ▸ | NPM1 | P06748 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | ROS1 | P08922 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL520421 | 0.88 | ALK (0.49) | ALKINSRNPM1EGFRJAK2 | |
| Trifluoroacetic Acid SCHEMBL520420 | 0.78 | ALK (0.64) | ALKINSRNPM1EGFRJAK2 | |
| SCHEMBL520848 | 0.77 | ALK (0.50) | ALKINSRNPM1EGFRJAK2 | |
| SCHEMBL520340 | 0.76 | INSR (0.52) | ALKINSRNPM1EGFRJAK2 | |
| SCHEMBL16531165 | 0.76 | ALK (0.70) | ALKINSRNPM1EGFRJAK2 | |
| SCHEMBL520313 | 0.75 | ALK (0.55) | ALKINSRNPM1EGFRJAK2 | |
| SCHEMBL519916 | 0.73 | ALK (0.66) | ALKINSRNPM1EGFRJAK2 | |
| SCHEMBL520774 | 0.72 | ALK (0.49) | ALKINSRNPM1EGFRJAK2 | |
| SCHEMBL520769 | 0.69 | INSR (0.39) | ALKINSRNPM1EGFRJAK2 | |
| SCHEMBL522104 | 0.69 | ALK (0.72) | ALKINSRNPM1JAK2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | claimed |