Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 9/20 | 0.84 |
| ▸ | MMP1 | P03956 | 3/20 | 0.69 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.69 |
| ▸ | MMP3 | P08254 | 2/20 | 0.67 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.63 |
| ▸ | MMP2 | P08253 | 3/20 | 0.54 |
| ▸ | MMP12 | P39900 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1504895 | 1.00 | ADAM17 (0.84) | ADAM17MMP1ADAM10MMP3ADAM9 | |
| SCHEMBL1504802 | 0.94 | ADAM17 (0.88) | ADAM17MMP1ADAM10MMP3ADAM9 | |
| SCHEMBL1504805 | 0.94 | ADAM17 (0.88) | ADAM17MMP1ADAM10MMP3ADAM9 | |
| SCHEMBL1504788 | 0.92 | ADAM17 (0.84) | ADAM17MMP1ADAM10MMP3ADAM9 | |
| SCHEMBL1504786 | 0.92 | ADAM17 (0.84) | ADAM17MMP1ADAM10MMP3ADAM9 | |
| SCHEMBL10276111 | 0.91 | ADAM17 (1.00) | ADAM17MMP1ADAM10MMP3ADAM9 | |
| SCHEMBL1504575 | 0.91 | ADAM17 (1.00) | ADAM17MMP1ADAM10MMP3ADAM9 | |
| SCHEMBL1503643 | 0.91 | ADAM17 (0.83) | ADAM17MMP1ADAM10MMP3MMP2 | |
| SCHEMBL1504702 | 0.89 | ADAM17 (0.84) | ADAM17MMP1ADAM10MMP3MMP2 | |
| SCHEMBL1504733 | 0.88 | ADAM17 (0.85) | ADAM17MMP1ADAM10MMP3ADAM9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033009-A1 | N- [2-HYDROXYCARBAMOYL-2- (PIPERAZINYL) ETHYL] BENZAMIDE COMPOUNDS, THEIR PREPARATION AND THEIR USE AS TACE INHIBITORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-03-24 | — | — | WO | disclosed |