Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 9/20 | 0.48 |
| ▸ | BRAF | P15056 | 9/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3710695 | 0.92 | RIPK1 (0.49) | RIPK1BRAFKDREPHB4TEK | |
| SCHEMBL15053340 | 0.90 | TRPV1 (0.48) | RIPK1BRAFKDRP2RY1 | |
| SCHEMBL15053326 | 0.90 | PDPK1 (0.39) | RIPK1BRAF | |
| SCHEMBL15052996 | 0.90 | BRAF (0.50) | RIPK1BRAFP2RY1 | |
| SCHEMBL15053798 | 0.89 | KDR (0.43) | RIPK1BRAFKDREPHB4TEK | |
| SCHEMBL15053782 | 0.89 | BRAF (0.50) | RIPK1BRAFKDREPHB4TEK | |
| SCHEMBL15052569 | 0.89 | PDPK1 (0.39) | RIPK1BRAF | |
| SCHEMBL15053044 | 0.89 | BRAF (0.43) | BRAFKDR | |
| SCHEMBL15053884 | 0.88 | MAPT (0.42) | BRAF | |
| SCHEMBL15052945 | 0.88 | KDR (0.40) | RIPK1BRAFKDREPHB4TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165475-A1 | DEUTERIUM-ENRICHED HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | ASCEPION PHARMACEUTICALS, INC. (CN) | 2013-06-27 | — | — | US | claimed |
| US-20130165475-A1 | DEUTERIUM-ENRICHED HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | ASCEPION PHARMACEUTICALS, INC. (CN) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165475-A1 | DEUTERIUM-ENRICHED HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | CDK2, CDK1, CDK3 | RIPK1 438/4885BRAF 90/4885KDR 1965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.