Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 19/20 | 0.50 |
| ▸ | RORA | P35398 | 2/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.50 |
| ▸ | RORB | Q92753 | 2/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15055037 | 0.96 | RORC (0.53) | RORCRORANR1H2NR1H3RORB | |
| SCHEMBL15054985 | 0.83 | RORC (0.69) | RORCRORANR1H2NR1H3RORB | |
| SCHEMBL15054953 | 0.77 | RORC (0.80) | RORCRORANR1H2NR1H3RORB | |
| SCHEMBL15054867 | 0.77 | RORC (0.60) | RORCRORANR1H2NR1H3RORB | |
| SCHEMBL15054990 | 0.77 | RORC (0.60) | RORCRORANR1H2NR1H3RORB | |
| SCHEMBL15055035 | 0.72 | RORC (0.64) | RORCRORANR1H2NR1H3RORB | |
| SCHEMBL15055740 | 0.72 | RORC (0.64) | RORCRORANR1H2NR1H3RORB | |
| SCHEMBL15071932 | 0.72 | RORC (0.64) | RORCRORANR1H2NR1H3RORB | |
| SCHEMBL12130664 | 0.70 | TSHR (0.47) | RORCRORBAOC3 | |
| SCHEMBL15054989 | 0.69 | RORC (0.65) | RORCRORANR1H2NR1H3RORB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794584-A1 | BENZYL SULFONAMIDE DERIVATIVES AS RORc MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013092941-A1 | BENZYL SULFONAMIDE DERIVATIVES AS RORc MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-06-27 | — | — | WO | disclosed |