Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 10/20 | 0.66 |
| ▸ | PFKFB4 | Q16877 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15056048 | 0.91 | PFKFB3 (0.75) | PFKFB3PFKFB4POLBSMN1; SMN2PLAU | |
| SCHEMBL15055734 | 0.88 | PFKFB3 (0.70) | PFKFB3PFKFB4ALDH1A1MAPTPOLB | |
| SCHEMBL15056062 | 0.88 | PFKFB3 (0.75) | PFKFB3PFKFB4ALDH1A1HPGDMEN1 | |
| SCHEMBL15055350 | 0.86 | PFKFB3 (0.87) | PFKFB3PFKFB4MAPTPOLBSMN1; SMN2 | |
| SCHEMBL15056582 | 0.86 | PFKFB3 (0.84) | PFKFB3PFKFB4ALDH1A1HPGDMEN1 | |
| SCHEMBL15055211 | 0.85 | PFKFB3 (0.67) | PFKFB3PFKFB4 | |
| SCHEMBL15055572 | 0.83 | PFKFB3 (0.63) | PFKFB3PFKFB4ALDH1A1LMNAMAPT | |
| SCHEMBL15055918 | 0.82 | PFKFB3 (0.57) | PFKFB3PFKFB4ALDH1A1LMNAHPGD | |
| SCHEMBL15055521 | 0.81 | PFKFB3 (0.59) | PFKFB3ALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL15056052 | 0.80 | PFKFB3 (0.57) | PFKFB3ALDH1A1LMNAHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794009-A1 | BISARYLSULFONAMIDES USEFUL IN THE TREATMENT OF INFLAMMATION AND CANCER | Kancera AB (SE) | 2014-10-29 | — | — | EP | claimed |
| WO-2013093095-A1 | BISARYLSULFONAMIDES USEFUL IN THE TREATMENT OF INFLAMMATION AND CANCER | KANCERA AB (SE) | 2013-06-27 | — | — | WO | claimed |
| EP-2794009-A1 | BISARYLSULFONAMIDES USEFUL IN THE TREATMENT OF INFLAMMATION AND CANCER | Kancera AB (SE) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013093095-A1 | BISARYLSULFONAMIDES USEFUL IN THE TREATMENT OF INFLAMMATION AND CANCER | KANCERA AB (SE) | 2013-06-27 | — | — | WO | disclosed |