Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 11/20 | 0.75 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.46 |
| ▸ | ABL1 | P00519 | 4/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15055743 | 0.92 | SCN9A (0.79) | SCN9ASCN5A | |
| SCHEMBL16242066 | 0.91 | SCN9A (0.65) | SCN9ASCN5AABL1 | |
| SCHEMBL15055750 | 0.91 | SCN9A (0.80) | SCN9ASCN5ARORC | |
| SCHEMBL10154795 | 0.88 | SCN9A (0.86) | SCN9ASCN5A | |
| SCHEMBL15075188 | 0.86 | SCN9A (1.00) | SCN9ASCN5A | |
| SCHEMBL15055296 | 0.86 | SCN9A (0.88) | SCN9ASCN5A | |
| SCHEMBL16242106 | 0.85 | SCN9A (0.70) | SCN9ASCN5A | |
| SCHEMBL15054825 | 0.85 | SCN9A (0.81) | SCN9ASCN5A | |
| SCHEMBL15055115 | 0.85 | SCN9A (0.81) | SCN9ASCN5A | |
| SCHEMBL15055297 | 0.84 | SCN9A (0.77) | SCN9ASCN5ARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013093688-A1 | SULFONAMIDE DERIVATIVES AND USE THEREOF AS VGSC INHIBITORS | PFIZER LIMITED (GB) | 2013-06-27 | — | — | WO | claimed |
| WO-2013093688-A1 | SULFONAMIDE DERIVATIVES AND USE THEREOF AS VGSC INHIBITORS | PFIZER LIMITED (GB) | 2013-06-27 | — | — | WO | disclosed |