Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 14/20 | 0.81 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | TEK | Q02763 | 2/20 | 0.41 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15055743 | 0.93 | SCN9A (0.79) | SCN9AMRGPRX4SCN5AKDRTEK | |
| SCHEMBL15055599 | 0.90 | SCN9A (1.00) | SCN9ASCN5A | |
| SCHEMBL16242041 | 0.89 | SCN9A (0.66) | SCN9AMRGPRX4SCN5AKDRTEK | |
| SCHEMBL15055456 | 0.89 | SCN9A (0.78) | SCN9AMRGPRX4SCN5A | |
| SCHEMBL15055489 | 0.87 | SCN9A (0.62) | SCN9ASCN5A | |
| SCHEMBL15055297 | 0.87 | SCN9A (0.77) | SCN9ASCN5A | |
| SCHEMBL15055760 | 0.85 | SCN9A (0.75) | SCN9ASCN5A | |
| SCHEMBL10154795 | 0.82 | SCN9A (0.86) | SCN9ASCN5A | |
| SCHEMBL16242187 | 0.82 | SCN9A (0.63) | SCN9AMRGPRX4SCN5AKDRTEK | |
| SCHEMBL15055296 | 0.82 | SCN9A (0.88) | SCN9AMRGPRX4SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013093688-A1 | SULFONAMIDE DERIVATIVES AND USE THEREOF AS VGSC INHIBITORS | PFIZER LIMITED (GB) | 2013-06-27 | — | — | WO | claimed |
| WO-2013093688-A1 | SULFONAMIDE DERIVATIVES AND USE THEREOF AS VGSC INHIBITORS | PFIZER LIMITED (GB) | 2013-06-27 | — | — | WO | disclosed |