Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | ATM | Q13315 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16260120 | 0.98 | ATM (0.55) | MEN1KMT2AATMRAB9ACYP2D6 | |
| SCHEMBL16260131 | 0.82 | KMT2A (0.58) | MEN1KMT2AATMRAB9ACYP2D6 | |
| SCHEMBL15079140 | 0.77 | ALDH1A1 (0.49) | MEN1KMT2AATMRAB9ANPC1 | |
| Bromide SCHEMBL15056150 | 0.76 | POLB (0.57) | MEN1KMT2ARAB9ACYP2D6TSHR | |
| Bromide SCHEMBL15347768 | 0.74 | BCHE (0.62) | MEN1KMT2AKDM4EPOLBALDH1A1 | |
| SCHEMBL15079141 | 0.74 | TSHR (0.56) | MEN1KMT2ARAB9ACYP2D6TSHR | |
| Iodide SCHEMBL15847467 | 0.70 | BCHE (0.59) | MEN1KMT2AKDM4EALDH1A1 | |
| Iodide SCHEMBL17423284 | 0.69 | MEN1 (1.00) | MEN1KMT2AATMRAB9ANPC1 | |
| Bromide SCHEMBL10776612 | 0.69 | CYP2D6 (0.97) | MEN1KMT2ACYP2D6TSHRHSD17B10 | |
| SCHEMBL455623 | 0.69 | ATM (0.56) | MEN1KMT2AATMRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140349297-A1 | FLUORESCENT DYES BASED ON ACRIDINE AND ACRIDINIUM DERIVATIVES | ALMAC SCIENCES (SCOTLAND) LIMITED (GB) | 2014-11-27 | — | — | US | disclosed |
| EP-2795324-A1 | FLUORESCENT DYES BASED ON ACRIDINE AND ACRIDINIUM DERIVATIVES | Almac Sciences (Scotland) Limited (GB) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013093481-A1 | FLUORESCENT DYES BASED ON ACRIDINE AND ACRIDINIUM DERIVATIVES | ALMAC SCIENCES (SCOTLAND) LIMITED (GB) | 2013-06-27 | — | — | WO | disclosed |